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TC11
CAS No. 100823-03-8
TC11 ( 1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 | CLT-003 )
产品货号. M23213 CAS No. 100823-03-8
TC11 是一种有效的肿瘤细胞增殖抑制剂，并通过激活 caspase-3、8 和 9 诱导细胞凋亡。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥275 | 有现货 |
|
| 5MG | ￥446 | 有现货 |
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| 10MG | ￥786 | 有现货 |
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| 25MG | ￥1604 | 有现货 |
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| 50MG | ￥2989 | 有现货 |
|
| 100MG | ￥4447 | 有现货 |
|
| 500MG | ￥9639 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称TC11
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述TC11 是一种有效的肿瘤细胞增殖抑制剂，并通过激活 caspase-3、8 和 9 诱导细胞凋亡。
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产品描述TC11 is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.
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体外实验TC11 (0~30 μM; 24 hours; KMS34 cells) induces cell death in KMS34.TC11 (5 μM; 0~48 hours; KMS34 cells) induces cell death occurs through an apoptotic pathway and downregulates MCL1 expression.TC11 (5 μM; 24 hours; KMS34 cells) induces M arrest. Cell Viability Assay Cell Line:KMS34 cells Concentration:0~30 μM Incubation Time:24 hours Result:Induced cell death.Western Blot Analysis Cell Line:KMS34 cells Concentration:5 μM Incubation Time:0~48 hours Result:Induced cell death occurs through an apoptotic pathway and downregulated MCL1 expression.Cell Cycle Analysis Cell Line:KMS34 cellsConcentration:5 μM Incubation Time:24 hours Result:Induced M arrest.
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体内实验——
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同义词1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 | CLT-003
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通路Apoptosis
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靶点Caspase
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受体caspase-3|caspase-8|caspase-9
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研究领域——
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适应症——
化学信息
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CAS Number100823-03-8
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分子量322.4
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分子式C20H22N2O2
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纯度>98% (HPLC)
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溶解度DMSO:10 mM
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SMILESCC(C)C1=C(C(=CC=C1)C(C)C)N2C(=O)C3=C(C2=O)C=C(C=C3)N
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Di A , Mn A , Wm A , et al. A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells - ScienceDirect[J]. Biochemical and Biophysical Research Communications, 2020, 521( 1):252-258.
