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TBOPP
CAS No. 1996629-79-8
TBOPP ( —— )
产品货号. M22123 CAS No. 1996629-79-8
TBOPP 是一种选择性 DOCK1 抑制剂 (IC50 : 8.4 μM)，对更广泛的肿瘤类型具有抗肿瘤活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3021 | 有现货 |
|
| 10MG | ￥3831 | 有现货 |
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| 25MG | ￥6294 | 有现货 |
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| 50MG | ￥8829 | 有现货 |
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| 100MG | ￥11826 | 有现货 |
|
| 500MG | ￥23733 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称TBOPP
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述TBOPP 是一种选择性 DOCK1 抑制剂 (IC50 : 8.4 μM)，对更广泛的肿瘤类型具有抗肿瘤活性。
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产品描述TBOPP is a selective DOCK1 inhibitor (IC50 : 8.4 μM), with anti-tumor activity for broader types of tumors. TBOPP as a selective inhibitor of DOCK1.?TBOPP dampened DOCK1-mediated invasion, macropinocytosis, and survival under the condition of glutamine deprivation without impairing the biological functions of the closely related DOCK2 and DOCK5 proteins.TBOPP treatment suppressed cancer metastasis and growth in vivo in mice.
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体外实验Cell Viability Assay Cell Line:3LL cells Concentration:12.5 μM Incubation Time:3 days Result:Inhibited cell viability.
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体内实验Animal Model:C57BL/6 mice (6- to 8-week-old) with ex-3LL cells Dosage:0.67 mg per mouse Administration:Administrated on days 0, 1, 3, and 5; for 2 weeks Result:The lung metastasis was significantly suppressed.
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同义词——
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通路Others
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靶点Other Targets
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受体DOCK1|DOCK1 DHR-2 domain
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研究领域——
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适应症——
化学信息
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CAS Number1996629-79-8
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分子量490.49
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分子式C24H21F3N2O4S
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纯度>98% (HPLC)
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溶解度DMSO:120 mg/mL (244.65 mM; Need ultrasonic)
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SMILESFC(F)(F)c1cccc(c1)-c1ccc(cc1)C(=O)Cn1cc(ccc1=O)S(=O)(=O)N1CCCC1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Tajiri H, et al. Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCKCell Rep. 2017 May 2;19(5):969-980.
