
TASIN-1
CAS No. 792927-06-1
TASIN-1 ( 1-[(4-methoxyphenyl)sulfonyl]-4'-methyl-4,1'-bipiperidine )
产品货号. M27609 CAS No. 792927-06-1
TASIN-1 是突变型腺瘤性大肠杆菌 (APC) 的小分子抑制剂。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥616 | 有现货 |
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10MG | ¥1077 | 有现货 |
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25MG | ¥2292 | 有现货 |
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50MG | ¥3686 | 有现货 |
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100MG | ¥5443 | 有现货 |
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500MG | ¥11583 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称TASIN-1
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述TASIN-1 是突变型腺瘤性大肠杆菌 (APC) 的小分子抑制剂。
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产品描述TASIN-1 is a small molecule inhibitor of mutant adenomatous polyposis coli (APC).(In Vitro):In two authentic human CRC cell lines HCT116 (WT APC) and DLD1 (truncated APC1417), TASIN-1 exhibited potent and selective toxicity toward DLD1 cells (IC50: 70 nM but not toward HCT116 cells (IC50 >50 μM)). TASIN-1 also reduced the endogenous cholesterol biosynthesis rate. TASIN-1 exerted its killing effects primarily by depleting cholesterol through inhibition of emopamil-binding protein (EBP) activity. However, knockdown of truncated APC (>90%) expression desensitized DLD1 cells to TASIN-1, suggesting that APC is required for TASIN-1’s cytotoxicity.(In Vivo):In nude mice with established DLD1 and HT29 tumors, intraperitoneal injection of TASIN-1 twice daily for 18 days reduced the size of tumor xenografts and tumor growth rates. TASIN-1 resulted in the appearance of apoptotic cells with fragmented nuclei and induced an increase in cleaved caspase 3 and cleaved PARP1. However, TASIN-1 did not inhibit tumor growth in HCT116 xenografts. In a genetically engineered CRC mouse model, TASIN-1 significantly reduced tumor formation in the colons of CPC .
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体外实验——
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体内实验——
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同义词1-[(4-methoxyphenyl)sulfonyl]-4'-methyl-4,1'-bipiperidine
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通路Others
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靶点Other Targets
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受体HBV|CYP1A2
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研究领域——
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适应症——
化学信息
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CAS Number792927-06-1
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分子量352.49
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分子式C18H28N2O3S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 25 mg/mL (70.92 mM)
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SMILESCOc1ccc(cc1)S(=O)(=O)N1CCC(CC1)N1CCC(C)CC1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Lou Y, et al. Metabolites characterization of chamaechromone in vivo and in vitro by using ultra-performance liquid chromatography/Xevo G2 quadrupole time-of-flight tandem mass spectrometry. J Ethnopharmacol. 2014;151(1):242-52.
产品手册




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