TAS120 ( Futibatinib | FGFR-IN-1 )

产品货号. M19782 CAS No. 1448169-71-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

TAS120
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

TAS-120是一种新型、强效、高选择性的FGFR抑制剂，用于抗肿瘤治疗。
产品描述

TAS-120 is a novel potent and highly selective FGFR inhibitor used for antitumor treatment.(In Vitro):Futibatinib (TAS-120) covalently binds to a highly conserved P-loop cysteine residue in the ATP pocket of FGFR.(In Vivo):Futibatinib (TAS-120) (3, 30, 100 mg/kg/day, p.o.) exerts an anti-tumor effect in mice. Futibatinib (TAS-120) shows anti-tumor effect by administering at moderate intervals, such as intermittent administration of every other day dosing and 2 times/week, and reducing the sustained elevation and weight suppression blood phosphorus level, and take a antitumor effective as daily administration.
体外实验

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体内实验

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同义词

Futibatinib | FGFR-IN-1
通路

Angiogenesis
靶点

FGFR
受体

FGFR
研究领域

Cancer
适应症

Solid tumours

CAS Number

1448169-71-8
分子量

418.45
分子式

C22H22N6O3
纯度

>98% (HPLC)
溶解度

DMSO:≥ 29 mg/mL (69.30 mM)
SMILES

COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12
化学全称

1-[(3S)-3-[4-amino-3-[2-(35-dimethoxyphenyl)ethynyl]-1H-pyrazolo[34-d]pyrimidin-1-yl]-1-pyrrolidinyl]-2-propen-1-one