TAS-102 ( TAS102, TAS-102, TAS 102, Trifluridine/tipiracil hydrochloride )

产品货号. M15805 CAS No. 733030-01-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

TAS-102
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

TAS-102 是一种治疗转移性结直肠 Y 型疾病的候选化合物。它含有三氟尿苷 (TFT) 和盐酸替匹拉西 (TTP)，摩尔比为 2:1。
产品描述

TAS-102 is an investigational drug candidate for metastatic colorectal Y. It contains trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a molar ratio of 2:1.
体外实验

——
体内实验

Animal Model:Male nude mice bearing KM12C, KM12C/5-FU, DLD-1, DLD-1/5-FU, and SC-2 cells Dosage:150 mg/kg/day Administration:p.o.; twice a day for 14 daysResult:Prevented body weight loss and reduced the relative tumor volume in colorectal cancer and gastric cancer mice models.
同义词

TAS102, TAS-102, TAS 102, Trifluridine/tipiracil hydrochloride
通路

Others
靶点

Other Targets
受体

Others
研究领域

——
适应症

——

CAS Number

733030-01-8
分子量

575.32
分子式

C19H23Cl2F3N6O7
纯度

>98% (HPLC)
溶解度

Soluble in DMSO
SMILES

O=C1NC(C(C(F)(F)F)=CN1[C@@H]2O[C@H](CO)[C@@H](O)C2)=O.O=C3NC(C(Cl)=C(CN4C(CCC4)=N)N3)=O.[H]Cl
化学全称

4-hydroxy-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(trifluoromethyl)pyrimidin-2(1H)-one compound with 5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4-diol (1:1) hydrochloride

1.Nukatsuka M, et al. anticancer Res. 2015 Sep;35(9):4605-15.

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