TAK-448 ( MVT-602 )

产品货号. M29793 CAS No. 1234319-68-6

TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM.TAK-448 has been used in trials studying the treatment of Prostate Cancer, Low Testosterone, Prostatic Neoplasms, and Hypogonadotropic Hypogonadism.

纯度: >98% (HPLC)

COA

Datasheet

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HPLC

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Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥2657	有现货
100MG	获取报价	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

TAK-448
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM.TAK-448 has been used in trials studying the treatment of Prostate Cancer, Low Testosterone, Prostatic Neoplasms, and Hypogonadotropic Hypogonadism.
产品描述

TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM.TAK-448 has been used in trials studying the treatment of Prostate Cancer, Low Testosterone, Prostatic Neoplasms, and Hypogonadotropic Hypogonadism.(In Vivo):TAK-448 (0.01-3 mg/kg; given i.h.; dosings on day 0 and 28) has greater anti-tumor effects in VCaP xenograft model.
体外实验

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体内实验

TAK-448 (0.01-3 mg/kg; given i.h.; dosings on day 0 and 28) has greater anti-tumor effects in VCaP xenograft model. Animal Model:Rat VCaP xenograft androgen-sensitive prostate cancer model (7-week-old rats)Dosage:0.01, 0.03, 0.3, 3 mg/kg Administration:Given i.h.; dosings on day 0 and 28 Result:Had greater anti-tumor effects in VCaP xenograft model.
同义词

MVT-602
通路

Others
靶点

Other Targets
受体

IC50: 460 pM (KISS1R)
研究领域

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适应症

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化学信息

CAS Number

1234319-68-6
分子量

1225.36
分子式

C58H80N16O14
纯度

>98% (HPLC)
溶解度

——
SMILES

——
化学全称

Sequence:Ac-D-Tyr-D-Trp-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

Nishizawa N, et al. Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly PotentTestosterone-Suppressive Activity and Excellent Water Solubility. J Med Chem. 2016 Oct 13;59(19):8804-8811.

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