T3Inh-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

T3Inh-1 is an effective and selective inhibitor of ppGalNAc-T3 with an IC50 of 7 μM. T3Inh-1 prevents breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects.

T3Inh-1 is an effective and selective inhibitor of ppGalNAc-T3 with an IC50 of 7 μM. T3Inh-1 prevents breast cancer cells. T3Inh-1 reduces FGF23 hormone levels in both tissue cells and mice, without causing any toxic side effects. (In Vitro):In HEK cells, T3Inh-1 (6h)increased the cleavage of FGF23. In MDA-MB231 cells, T3Inh-1(5 μM; 24h, 48h) inhibited migration by >80% and invasion by 98% while causing no discernable effect on cell proliferation. T3Inh-1 exhibited no toxicity and did not affect HEK cell proliferation.(In Vivo):In Wild-type C57BL/6 mice, T3Inh-1 (25, 50 mg/kg; i.p.) blocked ppGalNAc-T3-mediated glycan-masking of FGF23 and increased its cleavage.

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Others

Other Targets

5-HT3

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50440-30-7

476.5

C27H20N6O3

>98% (HPLC)

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[O-][N+](c(ccc1ncc2)cc1c2Nc(cc1)ccc1C(Nc(cc1)ccc1Nc1ccncc1)=O)=O

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(-20℃)

With Ice Pack

≥ 2 years