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T247
CAS No. 1451042-18-4
T247 ( T 247;HDAC3 inhibitor T247 )
产品货号. M11944 CAS No. 1451042-18-4
A potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 50MG | ￥8991 | 有现货 |
|
| 100MG | ￥13041 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称T247
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8.
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产品描述A potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8; induces dose-dependent selective increase of NF-κB acetylation in human colon cancer HCT116 cells, induces growth inhibition of cancer cells, and activates HIV gene expression in latent HIV-infected cells; shows promising activity for anticancer and antiviral benefits; also decreases TMEM16A expression and functional activity in both prostatic cancer cell line PC-3 and the breast cancer cell line YMB-1.
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同义词T 247;HDAC3 inhibitor T247
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通路Cell Cycle/DNA Damage
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靶点HDAC
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受体HDAC
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研究领域——
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适应症——
化学信息
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CAS Number1451042-18-4
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分子量389.48
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分子式C21H19N5OS
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(NC1=CC=CC=C1N)C2=CC=C(C3=CN(CCC4=CSC=C4)N=N3)C=C2
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化学全称N-(2-aminophenyl)-4-[1-(2-thiophen-3-ylethyl)-1H-[1],[2],[3]triazol-4-yl]benzamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Suzuki T, et al. PLoS One. 2013 Jul 16;8(7):e68669.
2. Matsuba S, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):510-8.
3. Methot JL, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):973-8.
2. Matsuba S, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):510-8.
3. Methot JL, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):973-8.
产品手册
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