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Syrosingopine

CAS No. 84-36-6

Syrosingopine ( —— )

产品货号. M22915 CAS No. 84-36-6

Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥1175 有现货
10MG ¥1806 有现货
25MG ¥3086 有现货
50MG ¥4633 有现货
100MG ¥6391 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Syrosingopine
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor.
  • 产品描述
    Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor.The anticancer activity of the widely used diabetic drug metformin is strongly potentiated by Syrosingopine. Synthetic lethality elicited by combining the two drugs is synergistic and specific to transformed cells. This effect is unrelated to Syrosingopine??s known role as an inhibitor of the vesicular monoamine transporters. Syrosingopine binds to the glycolytic enzyme α±-enolase in vitro, and the expression of the γ-enolase isoform correlates with nonresponsiveness to the drug combination. Syrosingopine sensitized cancer cells to metformin and its more potent derivative phenformin far below the individual toxic threshold of each compound.
  • 同义词
    ——
  • 通路
    GPCR/G Protein
  • 靶点
    Dopamine Receptor
  • 受体
    dopamine
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    84-36-6
  • 分子量
    666.71
  • 分子式
    C35H42N2O11
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO:62.5 mg/mL (93.74 mM; Need ultrasonic)
  • SMILES
    [H][C@@]12C(NC3=C4C=CC(OC)=C3)=C4CCN1C[C@]5(C[C@@H](OC(C6=CC(OC)=C(OC(OCC)=O)C(OC)=C6)=O)[C@H](OC)[C@@H](C(OC)=O)[C@]5(C2)[H])[H]
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Syrosingopine sensitizes cancer cells to killing by metforminSci. Adv.,2016 Dec; 2(12): e1601756.
产品手册
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