Syrosingopine
CAS No. 84-36-6
Syrosingopine ( —— )
产品货号. M22915 CAS No. 84-36-6
Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥1175 | 有现货 |
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10MG | ¥1806 | 有现货 |
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25MG | ¥3086 | 有现货 |
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50MG | ¥4633 | 有现货 |
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100MG | ¥6391 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Syrosingopine
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor.
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产品描述Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor.The anticancer activity of the widely used diabetic drug metformin is strongly potentiated by Syrosingopine. Synthetic lethality elicited by combining the two drugs is synergistic and specific to transformed cells. This effect is unrelated to Syrosingopine??s known role as an inhibitor of the vesicular monoamine transporters. Syrosingopine binds to the glycolytic enzyme α±-enolase in vitro, and the expression of the γ-enolase isoform correlates with nonresponsiveness to the drug combination. Syrosingopine sensitized cancer cells to metformin and its more potent derivative phenformin far below the individual toxic threshold of each compound.
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同义词——
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通路GPCR/G Protein
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靶点Dopamine Receptor
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受体dopamine
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研究领域——
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适应症——
化学信息
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CAS Number84-36-6
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分子量666.71
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分子式C35H42N2O11
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纯度>98% (HPLC)
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溶解度DMSO:62.5 mg/mL (93.74 mM; Need ultrasonic)
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SMILES[H][C@@]12C(NC3=C4C=CC(OC)=C3)=C4CCN1C[C@]5(C[C@@H](OC(C6=CC(OC)=C(OC(OCC)=O)C(OC)=C6)=O)[C@H](OC)[C@@H](C(OC)=O)[C@]5(C2)[H])[H]
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Syrosingopine sensitizes cancer cells to killing by metforminSci. Adv.,2016 Dec; 2(12): e1601756.
产品手册
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