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SynuClean-D

CAS No. 685121-45-3

SynuClean-D ( SC-D )

产品货号. M26472 CAS No. 685121-45-3

SynuClean-D 是一种 α-突触核蛋白聚集抑制剂,可防止帕金森病动物模型中原纤维传播、破坏成熟的淀粉样原纤维并消除多巴胺能神经元的变性。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥3029 有现货
10MG ¥4836 有现货
25MG ¥7808 有现货
50MG ¥10449 有现货
100MG ¥14256 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    SynuClean-D
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    SynuClean-D 是一种 α-突触核蛋白聚集抑制剂,可防止帕金森病动物模型中原纤维传播、破坏成熟的淀粉样原纤维并消除多巴胺能神经元的变性。
  • 产品描述
    SynuClean-D is an α-synuclein aggregation inhibitor preventing fibril propagation, disrupting mature amyloid fibrils, and abolishing the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease.(In Vitro):SynuClean-D prevents fibril propagation in protein-misfolding cyclic amplification assays and decreases the number of α-synuclein inclusions in human neuroglioma cells. SynuClean-D significantly reduces the aggregation of wild-type α-synuclein and the familiar A30P and H50Q variants in a substoichiometric molar ratio. SynuClean-D can bind to cavities in mature α-synuclein fibrils.(In Vivo):SynuClean-D-treated worms show decreased α-synuclein aggregation in muscle and a concomitant motility recovery. SynuClean-D is able to rescue dopaminergic neurons from α-synuclein-induced degeneration. In two parkinson’s disease (PD) Caenorhabditis elegans models, SynuClean-D expresses α-synuclein either in muscle or in dopaminergic neurons and significantly reduces the toxicity exerted by α-synuclein.
  • 体外实验
    SynuClean-D significantly reduces the in vitro aggregation of wild-type α-synuclein and the familiar A30P and H50Q variants in a substoichiometric molar ratio. SynuClean-D prevents fibril propagation in protein-misfolding cyclic amplification assays and decreases the number of α-synuclein inclusions in human neuroglioma cells. Computational analysis suggests that SynuClean-D can bind to cavities in mature α-synuclein fibrils and, indeed, it displays a strong fibril disaggregation activity.
  • 体内实验
    The treatment with SynuClean-D of two parkinson’s disease (PD) Caenorhabditis elegans models, expressing α-synuclein either in muscle or in dopaminergic neurons, significantly reduces the toxicity exerted by α-synuclein. SynuClean-D-treated worms show decreased α-synuclein aggregation in muscle and a concomitant motility recovery. More importantly, this compound is able to rescue dopaminergic neurons from α-synuclein-induced degeneration.
  • 同义词
    SC-D
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    PRPP Amidotransferase
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    685121-45-3
  • 分子量
    354.201
  • 分子式
    C13H5F3N4O5
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 83.33 mg/mL (235.26 mM)
  • SMILES
    Oc1nc(-c2cccc(c2)[N+]([O-])=O)c(c(c1C#N)C(F)(F)F)[N+]([O-])=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.ANISSIMOVA MARIA, ALLARD MATHIEU, MARLIERE PHILIPPE.Production of alkenes from 3-hydroxycarboxylic acids via 3-hydroxycarboxyl-nucleotidylic acids.CN105940111A
产品手册
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