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SynuClean-D
CAS No. 685121-45-3
SynuClean-D ( SC-D )
产品货号. M26472 CAS No. 685121-45-3
SynuClean-D 是一种 α-突触核蛋白聚集抑制剂,可防止帕金森病动物模型中原纤维传播、破坏成熟的淀粉样原纤维并消除多巴胺能神经元的变性。
纯度: >98% (HPLC)
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规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥3029 | 有现货 |
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10MG | ¥4836 | 有现货 |
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25MG | ¥7808 | 有现货 |
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50MG | ¥10449 | 有现货 |
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100MG | ¥14256 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称SynuClean-D
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述SynuClean-D 是一种 α-突触核蛋白聚集抑制剂,可防止帕金森病动物模型中原纤维传播、破坏成熟的淀粉样原纤维并消除多巴胺能神经元的变性。
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产品描述SynuClean-D is an α-synuclein aggregation inhibitor preventing fibril propagation, disrupting mature amyloid fibrils, and abolishing the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease.(In Vitro):SynuClean-D prevents fibril propagation in protein-misfolding cyclic amplification assays and decreases the number of α-synuclein inclusions in human neuroglioma cells. SynuClean-D significantly reduces the aggregation of wild-type α-synuclein and the familiar A30P and H50Q variants in a substoichiometric molar ratio. SynuClean-D can bind to cavities in mature α-synuclein fibrils.(In Vivo):SynuClean-D-treated worms show decreased α-synuclein aggregation in muscle and a concomitant motility recovery. SynuClean-D is able to rescue dopaminergic neurons from α-synuclein-induced degeneration. In two parkinson’s disease (PD) Caenorhabditis elegans models, SynuClean-D expresses α-synuclein either in muscle or in dopaminergic neurons and significantly reduces the toxicity exerted by α-synuclein.
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体外实验SynuClean-D significantly reduces the in vitro aggregation of wild-type α-synuclein and the familiar A30P and H50Q variants in a substoichiometric molar ratio. SynuClean-D prevents fibril propagation in protein-misfolding cyclic amplification assays and decreases the number of α-synuclein inclusions in human neuroglioma cells. Computational analysis suggests that SynuClean-D can bind to cavities in mature α-synuclein fibrils and, indeed, it displays a strong fibril disaggregation activity.
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体内实验The treatment with SynuClean-D of two parkinson’s disease (PD) Caenorhabditis elegans models, expressing α-synuclein either in muscle or in dopaminergic neurons, significantly reduces the toxicity exerted by α-synuclein. SynuClean-D-treated worms show decreased α-synuclein aggregation in muscle and a concomitant motility recovery. More importantly, this compound is able to rescue dopaminergic neurons from α-synuclein-induced degeneration.
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同义词SC-D
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通路Others
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靶点Other Targets
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受体PRPP Amidotransferase
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研究领域——
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适应症——
化学信息
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CAS Number685121-45-3
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分子量354.201
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分子式C13H5F3N4O5
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 83.33 mg/mL (235.26 mM)
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SMILESOc1nc(-c2cccc(c2)[N+]([O-])=O)c(c(c1C#N)C(F)(F)F)[N+]([O-])=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.ANISSIMOVA MARIA, ALLARD MATHIEU, MARLIERE PHILIPPE.Production of alkenes from 3-hydroxycarboxylic acids via 3-hydroxycarboxyl-nucleotidylic acids.CN105940111A
产品手册
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