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Synaptamide
CAS No. 162758-94-3
Synaptamide ( Docosahexaenoyl ethanolamide )
产品货号. M12411 CAS No. 162758-94-3
一种内源性 DHA 代谢物，可在体外和体内促进神经突生长、突触发生和突触功能。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Synaptamide
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种内源性 DHA 代谢物，可在体外和体内促进神经突生长、突触发生和突触功能。
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产品描述An endogenous DHA metabolite that promotes neurite growth, synaptogenesis, and synaptic function both in vitro and in vivo; significantly increased the number of MAP2 and Tuj-1-positive neurons with concomitant induction of PKA/CREB phosphorylation at low nM; induces neuronal differentiation of NSCs.
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体外实验Synaptamide (Dehydroepiandrosteron; DHEA) is a weak agonist at both CB1 and CB2 receptors.
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体内实验Synaptamide (10 mg/kg; subcutaneously; daily for 7 days) promotes cognitive recovery in rats subjected to mild traumatic brain injury (mTBI).Synaptamide (2-10 mg/kg; adult male C57BL/6J mice) reduced the levels of nociceptive and inflammatory pain-related behaviour over 60 min in the intraplantar formaldehyde assay via both intraperitoneal and local intraplantar administration. Animal Model:Male Wistar rats;260?±?20 g, age 3 months; mTBI model)Dosage:10 mg/kg Administration:Subcutaneously; daily for 7 days Result:Reversed the mTBI-induced cognitive deficits.
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同义词Docosahexaenoyl ethanolamide
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通路Apoptosis
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靶点PKA
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受体PKA
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研究领域Neurological Disease
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适应症——
化学信息
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CAS Number162758-94-3
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分子量371.5561
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分子式C24H37NO2
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纯度>98% (HPLC)
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溶解度10 mM in DMSO; Ethanol: 25 mg/mL
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SMILESCCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)NCCO
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化学全称4,7,10,13,16,19-Docosahexaenamide, N-(2-hydroxyethyl)-, (4Z,7Z,10Z,13Z,16Z,19Z)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Rashid MA, et al. J Neurochem. 2013 Jun;125(6):869-84.
2. Kim HY, et al. Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):114-20.
3. Rashid MA, et al. Neuropharmacology. 2016 Mar;102:174-85.
产品手册
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