Survodutide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Survodutide (BI 456906) 是一种有效的、选择性的胰高血糖素受体/GLP-1 受体 (GCGR/GLP-1R) 双重激动剂，在 CHO-K1 细胞中的 EC50 值分别为 0.52 nM 和 0.33 nM。Survodutide 是一种 29 个氨基酸的肽，是含有 C18 脂肪酸的有效酰化肽。Survodutide 通过增加能量消耗和减少食物摄入来实现强大的抗肥胖功效。

Survodutide (BI 456906) is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake.

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Animal Model:Male C57BL6/J mice pre-fed with a 60% HFD (22 weeks)Dosage:3, 10, 20, 30 nmol/kg Administration:SC; daily; 30 days Result:Dose-dependently reduced bodyweight from baseline by up to 32% at Day 28 at a dose of 30 nmol/kg.

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GPCR/G Protein

Glucagon Receptor

Glucagon Receptor

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2805997-46-8

4231.62

C192H289N47O61

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (23.63 mM; 超声助溶 )

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(-20℃)

With Ice Pack

≥ 2 years