Sulfometuron-methyl
CAS No. 74222-97-2
Sulfometuron-methyl ( DXP 5648; DXP-5648; DXP5648 )
产品货号. M27152 CAS No. 74222-97-2
Sulfometuron-methyl is a herbicide and also is an active antibacterial agent. It is an effective inhibitor of acetolactate synthase II and thus shows antibacterial properties.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥405 | 有现货 |
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10MG | ¥583 | 有现货 |
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25MG | ¥1045 | 有现货 |
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50MG | ¥1515 | 有现货 |
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100MG | ¥2155 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Sulfometuron-methyl
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Sulfometuron-methyl is a herbicide and also is an active antibacterial agent. It is an effective inhibitor of acetolactate synthase II and thus shows antibacterial properties.
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产品描述Sulfometuron-methyl is a herbicide and also is an active antibacterial agent. It is an effective inhibitor of acetolactate synthase II and thus shows antibacterial properties.(In Vitro):The sulfonylurea herbicide sulfometuron methyl inhibits the growth of several bacterial species. In the presence of L-valine, sulfometuron methyl inhibits Salmonella typhimurium, this inhibition can be reversed by L-isoleucine. Reversal of growth retardation by L-isoleucine, accumulation of guanosine 5'-diphosphate 3'-diphosphate (magic spot), and relA mutant hypersensitivity suggest sulfometuron methyl interference with branched-chain amino acid biosynthesis. Growth inhibition of S. typhimurium is mediated by sulfometuron methyl's inhibition of acetolactate synthase, the first common enzyme in the branched-chain amino acid biosynthetic pathway. Sulfometuron methyl exhibits slow-binding inhibition of acetolactate synthase isozyme II from S. typhimurium with an initial Ki of 660 +/- 60 nM and a final, steady-state Ki of 65 +/- 25 nM. Inhibition of acetolactate synthase by sulfometuron methyl is substantially more rapid (10 times) in the presence of pyruvate with a maximal first-order rate constant for conversion from initial to final steady-state inhibition of 0.25 +/- 0.07 min-1 (minimal half-time of 2.8 min). Mutants of S. typhimurium able to grow in the presence of sulfometuron methyl were obtained. They have acetolactate synthase activity that is insensitive to sulfometuron methyl because of mutations in or near ilvG, the structural gene for acetolactate synthase isozyme II.
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同义词DXP 5648; DXP-5648; DXP5648
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通路GPCR/G Protein
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靶点Antibacterial
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受体PPAR
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研究领域——
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适应症——
化学信息
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CAS Number74222-97-2
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分子量364.4
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分子式C15H16N4O5S
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纯度>98% (HPLC)
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溶解度——
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SMILESCOC(=O)c1ccccc1S(=O)(=O)NC(=O)Nc1nc(C)cc(C)n1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Lund?sen T, et al. The PPAR pan-agonist tetradecylthioacetic acid promotes redistribution of plasma cholesterol towards large HDL. PLoS One. 2020 Mar 16;15(3):e0229322.
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