Su1498 ( SU-1498; SU 1498; SU1498; Tyrphostin SU 1498 )

产品货号. M17363 CAS No. 168835-82-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Su1498
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM).
产品描述

SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1, 2 It effectively blocks signaling through VEGFR2 both in vitro and in vivo.1, 3 SU 1498 is used to study the role of VEGFR2 signaling in diverse processes, including angiogenesis, tumor growth, neural progenitor cell survival, and neuroregeneration.
同义词

SU-1498; SU 1498; SU1498; Tyrphostin SU 1498
通路

Others
靶点

Other Targets
受体

VEGFR2
研究领域

——
适应症

——

CAS Number

168835-82-3
分子量

390.53
分子式

C25H30N2O2
纯度

98%
溶解度

DMSO : ≥ 150 mg/mL. 384.10 mM
SMILES

O=C(/C(=C/c1cc(C(C)C)c(O)c(C(C)C)c1)/C#N)NCCCc1ccccc1
化学全称

(2E)-2-cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-2-propenamide

1: Gawlak G, et al.Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1062-70.

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