Stevioside ( Steviosin | CCRIS 6116 )

产品货号. M15116 CAS No. 57817-89-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Stevioside
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Stevioside 是从甜叶菊叶中提取的一种天然甜味剂，具有抗癌活性。
产品描述

A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anion transport system interference.
体外实验

Apoptosis Analysis Cell Line:MDA-MB-231 Concentration:10 μM Incubation Time:24 h Result:Increased the rate of apoptosis in cells with combination of 5-Fu (HY-90006).Increased ROS level significantly in MDA-MB-231. Combinated with 5-Fu (HY-90006) could trigger early and late apoptotic events in cancer cells.Western Blot AnalysisCell Line:THP-1 cells Concentration:1 mM Incubation Time:45 min Result:Inhibited the expression level of NF-κB and IKKβ.
体内实验

Animal Model:Balb/c miceDosage:6.25-25 mg/kg Administration:p.o., daily, 7 days Result:Didn’t show any change in the general behaviour of the test animals.Increased antibody synthesis of 15.38% and delayed type hypersensitivity (DTH) response of 18% at the dose of 12.5 mg/kg.
同义词

Steviosin | CCRIS 6116
通路

Others
靶点

Other Targets
受体

TLR2
研究领域

Metabolic Disease
适应症

——

CAS Number

57817-89-7
分子量

804.88
分子式

C38H60O18
纯度

>98% (HPLC)
溶解度

DMSO: 10 mM
SMILES

C=C([C@@](CC1)(O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C4)C[C@@]54CC[C@]6([H])[C@@](C(O[C@H]7[C@@H]([C@H]([C@@H]([C@@H](CO)O7)O)O)O)=O)(C)CCC[C@@]6(C)[C@@]51[H]
化学全称

(4alpha)-beta-D-Glucopyranosyl 13-((2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)kaur-16-en-18-oate

1.Wang T, et al. Int Immunopharmacol. 2014 Sep;22(1):192-9.

计算器

产品手册

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