Stepronin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Stepronin (Prostenoglycine) 是一种口服有效的祛痰剂 (吸入给药优于口服给药)。Stepronin 在体外通过减少上皮细胞的 Cl- 分泌和粘膜下腺体的粘液糖蛋白分泌来抑制气道分泌。

Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands.

Stepronin (0.1-100 μM; 20 min) induces significant reductions in ISOP(Isoproterenol)-evoked SCC (short circuit current) value in a dose-dependent manner in canine tracheal epithelium.Stepronin (10-100 μM; 20 min) significantly inhibits the basal secretion and ISOP-evoked PD (potential difference) value in a dose-dependent manner in canine tracheal epithelium.Stepronin (100 μM; 20 min) significantly inhibits ISOP-induced [3H]-glycoconjugate secretion in submucosal glands.Cell Viability Assay Cell Line: Canine tracheal epithelium (from adult and 10 to 25 kg-weight mongrel dogs of both sexes)Concentration:0.1-100 μM; 10-100 μMIncubation Time:20 min (pre-treat) Result:Significantly inhibited ISOP-induced SCC and PD values, as well as basal secretion. Cell Viability Assay Cell Line:Submucosal glands (from adult and 10 to 25 kg-weight mongrel dogs of both sexes) Concentration:100 μM Incubation Time:20 min (pre-treat) Result:Significantly inhibited ISOP- induced [3H]-glycoconjugate secretion.

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Others

Other Targets

Others

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72324-18-6

273.33

C10H11NO4S2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : ≥ 250 mg/mL (914.65 mM )

CC(SC(=O)c1cccs1)C(=O)NCC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years