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Spautin-1

CAS No. 1262888-28-7

Spautin-1 ( Spautin1 )

产品货号. M11101 CAS No. 1262888-28-7

Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥267 有现货
5MG ¥389 有现货
10MG ¥494 有现货
25MG ¥923 有现货
50MG ¥1677 有现货
100MG ¥2989 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Spautin-1
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM.
  • 产品描述
    Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM, inhibits USP10 and USP13 with IC50 of 0.6-0.7 uM, but not USP14; promotes cell death under starvation condition and inhibits autophagic cell death, selectively promotes the degradation of Vps34 complexes, reduces the levels of PtdIns3P in cells, but is not a direct inhibitor of class III PI3 kinase activity; promotes the degradation of p53 via inhibition of USP10, which can be inhibited in the presence of MG132; sensitizes ovarian cancer cells to cisplatin and PARP inhibitor (olaparib).
  • 同义词
    Spautin1
  • 通路
    Proteasome/Ubiquitin
  • 靶点
    DUB
  • 受体
    USP10;USP13
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    1262888-28-7
  • 分子量
    271.27
  • 分子式
    C15H11F2N3
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: 27.1 mg/mL (100 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    FC1=CC=C(CNC2=C3C=C(F)C=CC3=NC=N2)C=C1
  • 化学全称
    6-fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Liu J, et al. Cell. 2011 Sep 30;147(1):223-34.
2. Li Y, et al. Nat Commun. 2017 Jun 1;8:15752. doi: 10.1038/ncomms15752.
3. Mateo R, et al. J Virol. 2013 Feb;87(3):1312-21.
4. Vakifahmetoglu-Norberg H, et al. Genes Dev. 2013 Aug 1;27(15):1718-30.
产品手册
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