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Spautin-1
CAS No. 1262888-28-7
Spautin-1 ( Spautin1 )
产品货号. M11101 CAS No. 1262888-28-7
Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥267 | 有现货 |
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| 5MG | ￥389 | 有现货 |
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| 10MG | ￥494 | 有现货 |
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| 25MG | ￥923 | 有现货 |
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| 50MG | ￥1677 | 有现货 |
|
| 100MG | ￥2989 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Spautin-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM.
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产品描述Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM, inhibits USP10 and USP13 with IC50 of 0.6-0.7 uM, but not USP14; promotes cell death under starvation condition and inhibits autophagic cell death, selectively promotes the degradation of Vps34 complexes, reduces the levels of PtdIns3P in cells, but is not a direct inhibitor of class III PI3 kinase activity; promotes the degradation of p53 via inhibition of USP10, which can be inhibited in the presence of MG132; sensitizes ovarian cancer cells to cisplatin and PARP inhibitor (olaparib).
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同义词Spautin1
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通路Proteasome/Ubiquitin
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靶点DUB
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受体USP10;USP13
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研究领域Cancer
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适应症——
化学信息
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CAS Number1262888-28-7
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分子量271.27
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分子式C15H11F2N3
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纯度>98% (HPLC)
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溶解度DMSO: 27.1 mg/mL (100 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESFC1=CC=C(CNC2=C3C=C(F)C=CC3=NC=N2)C=C1
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化学全称6-fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Liu J, et al. Cell. 2011 Sep 30;147(1):223-34.
2. Li Y, et al. Nat Commun. 2017 Jun 1;8:15752. doi: 10.1038/ncomms15752.
3. Mateo R, et al. J Virol. 2013 Feb;87(3):1312-21.
4. Vakifahmetoglu-Norberg H, et al. Genes Dev. 2013 Aug 1;27(15):1718-30.
2. Li Y, et al. Nat Commun. 2017 Jun 1;8:15752. doi: 10.1038/ncomms15752.
3. Mateo R, et al. J Virol. 2013 Feb;87(3):1312-21.
4. Vakifahmetoglu-Norberg H, et al. Genes Dev. 2013 Aug 1;27(15):1718-30.
产品手册
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