Spautin-1
CAS No. 1262888-28-7
Spautin-1 ( Spautin1 )
产品货号. M11101 CAS No. 1262888-28-7
Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥267 | 有现货 |
|
5MG | ¥389 | 有现货 |
|
10MG | ¥494 | 有现货 |
|
25MG | ¥923 | 有现货 |
|
50MG | ¥1677 | 有现货 |
|
100MG | ¥2989 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Spautin-1
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM.
-
产品描述Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM, inhibits USP10 and USP13 with IC50 of 0.6-0.7 uM, but not USP14; promotes cell death under starvation condition and inhibits autophagic cell death, selectively promotes the degradation of Vps34 complexes, reduces the levels of PtdIns3P in cells, but is not a direct inhibitor of class III PI3 kinase activity; promotes the degradation of p53 via inhibition of USP10, which can be inhibited in the presence of MG132; sensitizes ovarian cancer cells to cisplatin and PARP inhibitor (olaparib).
-
同义词Spautin1
-
通路Proteasome/Ubiquitin
-
靶点DUB
-
受体USP10;USP13
-
研究领域Cancer
-
适应症——
化学信息
-
CAS Number1262888-28-7
-
分子量271.27
-
分子式C15H11F2N3
-
纯度>98% (HPLC)
-
溶解度DMSO: 27.1 mg/mL (100 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
-
SMILESFC1=CC=C(CNC2=C3C=C(F)C=CC3=NC=N2)C=C1
-
化学全称6-fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Liu J, et al. Cell. 2011 Sep 30;147(1):223-34.
2. Li Y, et al. Nat Commun. 2017 Jun 1;8:15752. doi: 10.1038/ncomms15752.
3. Mateo R, et al. J Virol. 2013 Feb;87(3):1312-21.
4. Vakifahmetoglu-Norberg H, et al. Genes Dev. 2013 Aug 1;27(15):1718-30.
2. Li Y, et al. Nat Commun. 2017 Jun 1;8:15752. doi: 10.1038/ncomms15752.
3. Mateo R, et al. J Virol. 2013 Feb;87(3):1312-21.
4. Vakifahmetoglu-Norberg H, et al. Genes Dev. 2013 Aug 1;27(15):1718-30.
产品手册
关联产品
-
NSC112200
NSC112200 is a chemical inhibitor of the EZH2 deubiquitinase ZRANB1 (at 10 uM), destabilizes EZH2.
-
PR-619
PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay.
-
USP30 inhibitor 18
USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.