Sotatercept ( —— )

产品货号. M36791 CAS No. 1001080-50-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Sotatercept
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Sotatercept (ACE-011) 是一种可溶性激活素受体 2A (ACVR2A) 型 IgG Fc 融合蛋白。Sotatercept 结合了激活素和生长分化因子，试图恢复生长促进和生长抑制信号通路之间的平衡。Sotatercept 在肺动脉高压、贫血、骨质流失、红细胞生成、多发性骨髓瘤 (MM) 溶骨性病变中有潜在的应用。
产品描述

Sotatercept (ACE-011) is a soluble activin receptor 2A (ACVR2A) type IgG Fc fusion protein. Sotatercept combines activin and growth differentiation factor to try to restore the balance between growth promotion and growth inhibition signal pathways. Sotatercept has potential application in pulmonary arterial hypertension, anemia, bone loss, erythropoiesis, multiple myeloma (MM) osteolytic lesions.
体外实验

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体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

TGF-beta/Smad
研究领域

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适应症

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1. Humbert M, et al. Sotatercept for the Treatment of Pulmonary Arterial Hypertension. N Engl J Med. 2021 Apr 1;384(13):1204-1215. ?

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