Solabegron

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Solabegron 是 β3-肾上腺素能受体的选择性激动剂，刺激表达人 β3-AR 的中国仓鼠卵巢细胞中 cAMP 的积累（EC50 ：22 nM）。它用于治疗膀胱过度活动症和肠易激综合症。

Solabegron is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladder and irritable bowel syndrome. (In Vivo):Solabegron (GW427353) at 3 mg/kg i.v. evokes an increase in micturition volume threshold that prevented the acetic acid-evoked decreases in dogs. The low dose (1 mg/kg) shows no significant activity.

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Solabegron (GW427353) at 3 mg/kg i.v. evokes an increase in micturition volume threshold that prevented the acetic acid-evoked decreases in dogs. The low dose (1 mg/kg) shows no significant activity. Animal Model:Adult female beagle dogs (6-10 kg).Dosage:1, 3 mg/kg.Administration:I.V. once.Result:Dosage of 3 mg/kg evoked an increase in micturition volume threshold.

GW 427353

Apoptosis

Adenosine Receptor

β3-adrenergic receptor

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252920-94-8

410.89

C23H23ClN2O3

>98% (HPLC)

DMSO:250 mg/mL (608.44 mM; Need ultrasonic)

C1=CC(=CC(=C1)C(=O)O)C2=CC(=CC=C2)NCCNC[C@@H](C3=CC(=CC=C3)Cl)O

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(-20℃)

With Ice Pack

≥ 2 years