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Senecionine

CAS No. 130-01-8

Senecionine ( Senecionan-1116-dione 12-hydroxy- | Aureine | Senecionin )

产品货号. M21668 CAS No. 130-01-8

千里光碱是从千里光中分离出来的具有肝毒性的吡咯里西啶生物碱。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥1588 有现货
10MG ¥2390 有现货
25MG ¥4026 有现货
50MG ¥5856 有现货
100MG ¥7995 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Senecionine
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    千里光碱是从千里光中分离出来的具有肝毒性的吡咯里西啶生物碱。
  • 产品描述
    Senecionine is the hepatotoxic pyrrolizidine alkaloids isolated from Senecio vulgaris.
  • 体外实验
    Pyrrolizidine alkaloids (PAs) are considered to be one of the most hepatotoxic groups of compounds of plant origin and are present in about 3% of the world's flowering plants. Most PAs represent a considerable health hazard to both livestock and humans through the consumption of plants and PA-contaminated products such as milk, honey, herbal teas, and medicines.
  • 体内实验
    Upon intravenous administration and oral administration of Senecionine and Adonifoline, significant differences in pharmacokinetics were observed, with the Senecionine and Adonifoline being absorbed fast with lower bioavailability and being quickly metabolized to PA N-oxides and hydroxylation products of PAs or their N-oxides. Senecionine fails to stimulate epoxide hydrase, it diminishs the activity of glutathione-s-transferase, aminopyrine demethylase and AHH. Twice-weekly injections of a third constituent, senecionine, beginning on Day 12 or later, results in premature deliveries in three of seven rats, and the pups from all litters are stillborn or die shortly after birth.
  • 同义词
    Senecionan-1116-dione 12-hydroxy- | Aureine | Senecionin
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    130-01-8
  • 分子量
    335.39
  • 分子式
    C18H25NO5
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: 5 mg/mL (14.91 mM);Ethanol: 1 mg/mL (2.98 mM)
  • SMILES
    C[C@H](C/C(/C(O[C@H](CC1)[C@@H]2N1CC=C2COC1=O)=O)=C/C)[C@@]1(C)O
  • 化学全称
    (16)Dioxacyclododecino(234-gh)pyrrolizine-27-dione 3-ethylidene-3456911131414a14b-decahydro-6-hydroxy-56-dimethyl- (3Z5R6R14aR14bR)-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.D S Griffin et al. Effects of the Pyrrolizidine Alkaloid Senecionine and the Alkenals trans-4-OH-hexenal and trans-2-hexenal on Intracellular Calcium Compartmentation in Isolated Hepatocytes. Biochem Pharmacol. 1989 Feb 1; 38 (3) 391-7
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