
Senecionine
CAS No. 130-01-8
Senecionine ( Senecionan-1116-dione 12-hydroxy- | Aureine | Senecionin )
产品货号. M21668 CAS No. 130-01-8
千里光碱是从千里光中分离出来的具有肝毒性的吡咯里西啶生物碱。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥1588 | 有现货 |
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10MG | ¥2390 | 有现货 |
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25MG | ¥4026 | 有现货 |
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50MG | ¥5856 | 有现货 |
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100MG | ¥7995 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Senecionine
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述千里光碱是从千里光中分离出来的具有肝毒性的吡咯里西啶生物碱。
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产品描述Senecionine is the hepatotoxic pyrrolizidine alkaloids isolated from Senecio vulgaris.
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体外实验Pyrrolizidine alkaloids (PAs) are considered to be one of the most hepatotoxic groups of compounds of plant origin and are present in about 3% of the world's flowering plants. Most PAs represent a considerable health hazard to both livestock and humans through the consumption of plants and PA-contaminated products such as milk, honey, herbal teas, and medicines.
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体内实验Upon intravenous administration and oral administration of Senecionine and Adonifoline, significant differences in pharmacokinetics were observed, with the Senecionine and Adonifoline being absorbed fast with lower bioavailability and being quickly metabolized to PA N-oxides and hydroxylation products of PAs or their N-oxides. Senecionine fails to stimulate epoxide hydrase, it diminishs the activity of glutathione-s-transferase, aminopyrine demethylase and AHH. Twice-weekly injections of a third constituent, senecionine, beginning on Day 12 or later, results in premature deliveries in three of seven rats, and the pups from all litters are stillborn or die shortly after birth.
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同义词Senecionan-1116-dione 12-hydroxy- | Aureine | Senecionin
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number130-01-8
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分子量335.39
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分子式C18H25NO5
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纯度>98% (HPLC)
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溶解度DMSO: 5 mg/mL (14.91 mM);Ethanol: 1 mg/mL (2.98 mM)
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SMILESC[C@H](C/C(/C(O[C@H](CC1)[C@@H]2N1CC=C2COC1=O)=O)=C/C)[C@@]1(C)O
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化学全称(16)Dioxacyclododecino(234-gh)pyrrolizine-27-dione 3-ethylidene-3456911131414a14b-decahydro-6-hydroxy-56-dimethyl- (3Z5R6R14aR14bR)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.D S Griffin et al. Effects of the Pyrrolizidine Alkaloid Senecionine and the Alkenals trans-4-OH-hexenal and trans-2-hexenal on Intracellular Calcium Compartmentation in Isolated Hepatocytes. Biochem Pharmacol. 1989 Feb 1; 38 (3) 391-7
产品手册




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