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Saridegib
CAS No. 1037210-93-7
Saridegib ( Patidegib | IPI-926 )
产品货号. M10185 CAS No. 1037210-93-7
Saridegib (Patidegib, IPI-926) 是一种有效的口服活性 Hedgehog (Hh) 通路拮抗剂，IC50 为 7 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥15957 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Saridegib
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Saridegib (Patidegib, IPI-926) 是一种有效的口服活性 Hedgehog (Hh) 通路拮抗剂，IC50 为 7 nM。
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产品描述Saridegib (Patidegib, IPI-926) is a potent and orally active Hedgehog (Hh) pathway antagonist with IC50 of 7 nM; binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO; demonstrates improved pharmaceutical properties and potency and a favorable pharmacokinetic profile relative to cyclopamine and IPI-269609; completely suppresses tumor growth in a Hh-dependent medulloblastoma allograft model.Pancreatic Cancer Phase 2 Clinical.
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体外实验——
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体内实验Evidence from a genetically engineered mouse model of pancreatic cancer demonstrates that Saridegib (IPI-926) can deplete tumor-associated stromal tissue and increase intratumoral mean vessel density. These changes result in enhanced delivery of concurrently administered systemic agents, leading to a decreased tumor burden and prolonged survival in this mouse model.
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同义词Patidegib | IPI-926
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通路Wnt/Notch/Hedgehog
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靶点Smoothened (Smo)
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受体Smoothened (Smo)
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研究领域Cancer
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适应症Pancreatic Cancer
化学信息
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CAS Number1037210-93-7
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分子量504.768
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分子式C29H48N2O3S
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纯度>98% (HPLC)
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溶解度——
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SMILESCS(=O)(N[C@H](CC[C@@]12C)C[C@@]1([H])CC[C@]3([H])[C@]2([H])CC4=C(C)C[C@@](O5)(CC[C@@]34[H])[C@H](C)[C@@]6([H])[C@@]5([H])C[C@H](C)CN6)=O
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化学全称N-((2S,3R,3aS,3'R,4a'R,6S,6a'R,6b'S,7aR,12a'S,12b'S)-3,6,11',12b'-tetramethyl-2',3a,3',4,4',4a',5,5',6,6',6a',6b',7,7a,7',8',10',12',12a',12b'-icosahydro-1'H,3H-spiro[furo[3,2-b]pyridine-2,9'-naphtho[2,1-a]azulen]-3'-yl)methanesulfonamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Olive KP, et al. Science. 2009 Jun 12;324(5933):1457-61.
2. Tremblay MR, et al. J Med Chem. 2009 Jul 23;52(14):4400-18.
3. Lee MJ, et al. Proc Natl Acad Sci U S A. 2012 May 15;109(20):7859-64.
