Saralasin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Competitive non-selective angiotensin II antagonist.

Competitive non-selective angiotensin II antagonist.

Saralasin (1 nM, 48 or 72 h) inhibits cell growth in 3T3 and SV3T3 cells.Saralasin (5 μM, 2h) restores Ito, fast (Fast-Inactivating Transient Outward K+ Current in Mouse Ventricle) and I K, slow (Slow-Inactivating Transient Outward K+ Current in Mouse Ventricl) to control levels in myocytes.Saralasin (0.1-10 nM, 40 min) inhibits binding of FITC-Ang II to rat liver membrane preparation (used as the source of angiotensin receptors) with a Ki value of 0.32 nM for 74% of the binding sites and 2.7 nM for the remaining binding sites.Saralasin (1 μM, perfused rat ovary in vitro) inhibits the ovulation rate versus control and reduces prostaglandin E2 and 6-keto-prostaglandin F1α levels. Cell Proliferation Assay Cell Line:3T3 and SV3T3 cells Concentration:1 nM Incubation Time:48 h, 72 hResult:Inhibited cell growth in 3T3 and SV3T3 cells and caused an increase of cellular renin concentration.

Saralasin (intravenous injection, 5-50μg/kg, a single dose) ameliorates the oxidative stress and tissue injury in cerulein-induced pancreatitis.Saralasin (subcutaneous injection, 10 and 30 mg/kg, a single dose) increases serum renin activity (SRA) in normal, conscious rats, without markedly altering blood pressure or heart rate. Animal Model:Cerulein-induced acute pancreatitis rats model Dosage:5, 10, 20, and 50 μg/kg, a single dose.Administration:Intravenous injection Result:Restored the pancreatic morphological characteristics to the control level.Reduced pancreatic injury and suppressed the glutathione depletion induced by cerulean.Animal Model:Male Sprague-Dawley rats Dosage:10 and 30 mg/kg, a single dose.Administration:Subcutaneous injection Result:Stimulated renin release without altering blood pressure or heart rate at the time of measuring serum renin levels 20 minutes after injection.

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GPCR/G Protein

Angiotensin Receptor

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34273-10-4

912

C42H65N13O10

>98% (HPLC)

water:1 mg/mL

[H]N(C)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years