Salmeterol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

沙美特罗是一种长效β2-肾上腺素受体（β2AR）激动剂，用于治疗哮喘。

Salmeterol is a long-acting agonist of beta2-adrenergic receptor (beta 2AR) used for treatment ofasthma.

Cell Proliferation Assay Cell Line:Human T lymphocytes (THP-1 cells) Concentration:0.001, 0.01, 0.05, 0.2, 1, 5, and 25 μM Incubation Time:Result:The proliferation of Th2 cells was inhibited in a concentration dependent manner.

Animal Model:Male C57BL/6 mice (6-8 weeks old, body weight: 32-35 g)Dosage:Salmeterol (0.16 mg/kg) and/or Formoterol (0.32 mg/kg) Administration:The therapeutic efficacy of co-treatment was investigated in this model over a 56-day-long observation period.Result:COPD assessment test scores were markedly improved in mice with COPD.

GR33343X

Apoptosis

Adenosine Receptor

β2-adrenoceptor

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89365-50-4

415.57

C25H37NO4

>98% (HPLC)

DMSO:100 mg/mL (240.63 mM)

OC1=CC=C(C(O)CNCCCCCCOCCCCC2=CC=CC=C2)C=C1CO

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(-20℃)

With Ice Pack

≥ 2 years