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Salinomycin
CAS No. 53003-10-4
Salinomycin ( AHR 3096 | AHR3096 | AHR-3096 | K 364 | Salinomycin | BioCox | Sacox | Salocin | Coxistac )
产品货号. M14878 CAS No. 53003-10-4
Salinomycin 是一种 Wnt/β-catenin 信号传导抑制剂，作用于 Wnt/Fzd/LRP 复合物。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥365 | 有现货 |
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| 5MG | ￥599 | 有现货 |
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| 10MG | ￥956 | 有现货 |
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| 25MG | ￥1774 | 有现货 |
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| 50MG | ￥3151 | 有现货 |
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| 100MG | ￥4520 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Salinomycin
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Salinomycin 是一种 Wnt/β-catenin 信号传导抑制剂，作用于 Wnt/Fzd/LRP 复合物。
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产品描述Salinomycin is an inhibitor of Wnt/β-catenin signaling, which acts on the Wnt/Fzd/LRP complex. Salinomycin strongly suppresses Wnt1-stimulated reporter activity with an IC50 of 163 nM, and reduces β-catenin levels.
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体外实验——
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体内实验——
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同义词AHR 3096 | AHR3096 | AHR-3096 | K 364 | Salinomycin | BioCox | Sacox | Salocin | Coxistac
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通路Wnt/Notch/Hedgehog
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靶点Wnt/beta/catenin
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受体IC50: 163 nM (Wnt1-stimulated reporter)
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研究领域Infection
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适应症——
化学信息
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CAS Number53003-10-4
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分子量751
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分子式C??H??O??
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纯度>98% (HPLC)
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溶解度DMSO:≥ 36.7mg/mL In vivo: Add solvents to the product individually and in order: 10% DMSO+40% PEG300+5% Tween-80+45% saline (clear) ≥2mg/mL ；10% DMSO+90% corn oil (clear) ≥2mg/mL
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SMILESCC[C@@H](C(O)=O)[C@H]1CC[C@@H]([C@H]([C@H]([C@@H]([C@@H](C([C@@H]([C@H]2O[C@]3([C@@H](C[C@@H]2C)C)O[C@]4([C@@H](C=C3)O)CC[C@](O4)([C@H]5CC[C@](CC)([C@@H](O5)C)O)C)CC)=O)C)O)C)O1)C
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化学全称(R)-2-((2R,5S,6R)-6-((2S,3S,4S,6R)-6-((2S,5S,7R,9S,10S,12R,15R)-2-((2R,5R,6S)-5-ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl)-3-hydroxy-4-methyl-5-oxooctan-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)butanoic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Lu D, et al. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc natl Acad Sci U S A. 2011 Aug 9;108(32):13253-7.
2. Zhou J, et al. Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactiveoxygen species. Toxicol Lett. 2013 Oct 24;222(2):139-45.
