SW-033291

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

15-PGDH 的有效选择性抑制剂，Ki 为 0.1 nM，IC50 为 1.5 nM； 500 nM 时，PGE2 水平增加 3.5 倍，EC50 为 75 nM。

A potent and selective inhibitor of 15-PGDH with Ki of 0.1 nM, IC50 of 1.5 nM; increases PGE2 levels by 3.5-fold at 500 nM, with EC50 of 75 nM; increases prostaglandin PGE2 levels in bone marrow and other tissues, accelerates hematopoietic recovery in mice receiving a bone marrow transplant; also promotes tissue regeneration in mouse models of colon and liver injury.

Treating cells with SW033291 decreases cellular 15-PGDH enzyme activity by 85%. SW033291 inhibition of 15-PGDH was non-competitive versus PGE2 over concentrations up to 40 μM PGE2. Treatment of A549 cells with SW033291 increases PGE2 levels by 3.5-fold at 500 nM, with an EC50 50 at approximately 75 nM.

SW033291 (10 mg/kg; intraperitoneal injection; twice daily; for 3 days; C57BL/6J mice) treatment for three consecutive days shows significant benefits, including a doubling of peripheral neutrophil counts, a 65% increase in marrow SKL cells, and a 71% increase in marrow SLAM cells. Animal Model:C57BL/6J miceDosage:10 mg/kg Administration:Intraperitoneal injection; twice daily; for 3 days ( for 5 doses) Result:Showed significant benefits, including a doubling of peripheral neutrophil counts, a 65% increase in marrow SKL cells, and a 71% increase in marrow SLAM cells.

SW033291

Metabolic Enzyme/Protease

15-PGDH

15-PGDH

Other Indications

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459147-39-8

412.5913

C21H20N2OS3

>98% (HPLC)

10 mM in DMSO

NC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21

Thieno[2,3-b]pyridin-3-amine, 2-(butylsulfinyl)-4-phenyl-6-(2-thienyl)-

(-20℃)

With Ice Pack

≥ 2 years