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STF-62247
CAS No. 315702-99-9
STF-62247 ( STF62247 | STF 62247 )
产品货号. M14025 CAS No. 315702-99-9
STF-62247是一种小分子自噬诱导剂，可诱导自噬并选择性诱导VHL缺陷的RCC细胞致死；以不依赖于 HIF 的方式诱导细胞毒性并减少 VHL 缺陷细胞中的肿瘤生长，PI3K 和高尔基体运输是 STF-62247 诱导自噬中的初始信号。肾癌，临床前
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥251 | 有现货 |
|
| 10MG | ￥373 | 有现货 |
|
| 25MG | ￥794 | 有现货 |
|
| 50MG | ￥1377 | 有现货 |
|
| 100MG | ￥2406 | 有现货 |
|
| 200MG | ￥3702 | 有现货 |
|
| 500MG | ￥5978 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称STF-62247
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述STF-62247是一种小分子自噬诱导剂，可诱导自噬并选择性诱导VHL缺陷的RCC细胞致死；以不依赖于 HIF 的方式诱导细胞毒性并减少 VHL 缺陷细胞中的肿瘤生长，PI3K 和高尔基体运输是 STF-62247 诱导自噬中的初始信号。肾癌，临床前
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产品描述STF-62247 is a small molecule Autophagy inducer that induces autophagy and selectively induces lethality in VHL-deficient RCC cells; induces cytotoxicity and reduces tumor growth in VHL-deficient cells in a HIF-independent manner, PI3K and Golgi trafficking are required as initial signals in STF-62247-induced autophagy.Kidney Cancer Preclinical.
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体外实验In RCC4, RCC4/VHL, SN12C, SN12C-VHL shRNA cells, STF-62247 (0-30 μM) is selectively toxic to VHL-deficient cells compared to their VHL wild-type counterparts.STF-62247-treated cells accumulated intracytoplasmic vacuoles characteristic of cells undergoing autophagy. Moreover, these vacuoles are larger in VHL-deficient RCC4 and SN12C-VHL shRNA cells than in wild-type VHL cells.
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体内实验STF-62247 (2.7-8 mg/kg; intraperitoneal injection; daily; for 9 days) treatment significantly reduces tumor growth of VHL-deficient cells. Animal Model:SCID mice implanted with SN12C-VHL shRNA cells Dosage:2.7 mg/kg, or 8 mg/kg Administration:Intraperitoneal injection; daily; for 9 days Result:Significantly reduced tumor growth of VHL-deficient cells.
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同义词STF62247 | STF 62247
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通路Autophagy
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靶点Autophagy
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受体ER
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研究领域Cancer
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适应症Kidney Cancer
化学信息
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CAS Number315702-99-9
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分子量267.3488
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分子式C15H13N3S
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 31 mg/mL
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SMILESCC1=CC(NC2=NC(C3=CC=NC=C3)=CS2)=CC=C1
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化学全称2-Thiazolamine, N-(3-methylphenyl)-4-(4-pyridinyl)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Turcotte S, et al. Cancer Cell. 2008 Jul 8;14(1):90-102.
2. Turcotte S, et al. Autophagy. 2008 Oct;4(7):944-6.
3. Chan DA, et al. Cell Cycle. 2008 Oct;7(19):2987-90.
4.?Kozako T, et al. Oncotarget. 2018 Jun 12;9(45):27645-27655.
产品手册
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