ST-034307

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ST-034307 (ST 034307, ST034307) 是一种有效的选择性腺苷酸环化酶 1 (AC1)，IC50 为 2.3 uM。

ST-034307 (ST 034307, ST034307) is a potent, selective adenylyl cyclase 1 (AC1) with IC50 of 2.3 uM; shows no activity against other AC isoforms; inhibits Ca2+-stimulated cAMP accumulation in HEK cells, also inhibits AC1 activity stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells; reduces pain responses in a mouse model of inflammatory pain.

ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 significantly inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. In contrast, ST034307 has no significant effects in the wild-type HEK cells. ST034307 significantly inhibits the Ca2+/calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of MOR-mediated sensitization of AC1.

ST034307 (0.25 μg) causes a significant relief of CFA-induced inflammatory pain in mice. ST034307 exhibits an estimated median effective dose (E50) value for analgesia of 0.28 μg in the mouse pain model.

ST 034307 | ST034307

Metabolic Enzyme/Protease

Adenylate Cyclase

Adenylate Cyclase

Neurological Disease

——

133406-29-8

297.95

C10H4Cl4O2

>98% (HPLC)

DMSO : 50 mg/mL 167.81 mM

O=C1C=C(C(Cl)(Cl)Cl)OC2=C1C=C(Cl)C=C2

6-chloro-2-(trichloromethyl)-4H-chromen-4-one

(-20℃)

With Ice Pack

≥ 2 years