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SSR125543
CAS No. 752253-39-7
SSR125543 ( Crinecerfont | SSR-125543 )
产品货号. M15862 CAS No. 752253-39-7
SSR125543 (Crinecerfont, SSR-125543) 是一种有效的非肽、口服活性促肾上腺皮质激素释放因子 (CRF) 受体 CRF1 拮抗剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥2373 | 有现货 |
|
| 5MG | ￥3637 | 有现货 |
|
| 10MG | ￥5338 | 有现货 |
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| 25MG | ￥7995 | 有现货 |
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| 50MG | ￥11259 | 有现货 |
|
| 100MG | ￥15228 | 有现货 |
|
| 500MG | ￥30618 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称SSR125543
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述SSR125543 (Crinecerfont, SSR-125543) 是一种有效的非肽、口服活性促肾上腺皮质激素释放因子 (CRF) 受体 CRF1 拮抗剂。
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产品描述SSR125543 (Crinecerfont, SSR-125543) is a potent, nonpeptide, orally active corticotropin-releasing factor (CRF) receptor CRF1 antagonist, shows anxiolytic- and antidepressant-like activities in vivo. Depression Phase 2 Discontinued.
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体外实验——
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体内实验——
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同义词Crinecerfont | SSR-125543
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通路GPCR/G Protein
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靶点CRF Receptor
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受体CRF Receptor
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研究领域Neurological Disease
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适应症Depression
化学信息
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CAS Number752253-39-7
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分子量483.042
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分子式C27H28ClFN2OS
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纯度>98% (HPLC)
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溶解度——
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SMILESCC1=C(C=C(C=C1)C(CC2CC2)N(CC#C)C3=NC(=C(S3)C)C4=C(C=C(C(=C4)C)OC)Cl)F
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化学全称4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(prop-2-yn-1-yl)-1,3-thiazol-2-amine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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Urotensin I
Urotensin I is, 41-aa neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively. Urotensin-I was first isolated from the urophysis of the white sucker, and has been shown to decrease blood pressure in the rat. UI consists of 41 aa residues with an amidated C-terminus.
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Urocortin III, mouse
Mouse UcnIII is expressed predominantly in regions of the brain known to be involved in stress-related behaviours, and its expression in the hypothalamus increases following restraint.
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CRF, bovine
CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM.
