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SRX3207
CAS No. 2254693-15-5
SRX3207 ( —— )
产品货号. M33816 CAS No. 2254693-15-5
SRX3207 是具有口服活性的、首创的 Syk/PI3K 双抑制剂，其对 Syk 和 PI3Kα 的 IC50 值分别为 10.7 nM 和 861 nM。SRX3207 缓解抗肿瘤免疫抑制。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1098 | 有现货 |
|
| 5MG | ￥1752 | 有现货 |
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| 10MG | ￥2624 | 有现货 |
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| 25MG | ￥4113 | 有现货 |
|
| 50MG | ￥5419 | 有现货 |
|
| 100MG | ￥7436 | 有现货 |
|
| 500MG | ￥14918 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称SRX3207
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述SRX3207 是具有口服活性的、首创的 Syk/PI3K 双抑制剂，其对 Syk 和 PI3Kα 的 IC50 值分别为 10.7 nM 和 861 nM。SRX3207 缓解抗肿瘤免疫抑制。
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产品描述SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression.
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体外实验SRX3207 (10 μmol/L) is able to block p-AKT at concentration.SRX3207 has sufficient solubility in water (43 μmol/L).
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体内实验SRX3207 (10 mg/kg, orally) increases antitumor immune response.Animal Model:LLC or B16 or B16-OVA or CT26 (1 × 105) cells were injected subcutaneously into syngeneic mice.Dosage:10 mg/kg.Administration:Orally, starting from day 10 when tumors reached 100 mm3 until tumors were harvested on day 21.Result:Blocked phosphorylation of Syk at 348 site and Y525/526 site.Blocked immunosuppressive MΦ polarization.Blocked tumor growth and increased survival effectively.
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同义词——
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通路PI3K/Akt/mTOR signaling
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靶点PI3K
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受体PI3K | Syk
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研究领域——
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适应症——
化学信息
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CAS Number2254693-15-5
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分子量555.65
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分子式C29H29N7O3S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 5 mg/mL (9.00 mM; 超声助溶 )
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SMILESCc1nn(cc1CN1CCC1)-c1ccnc(Nc2ccc(cc2)-c2csc3c2oc(cc3=O)N2CCOCC2)n1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Shweta Joshi, et al. Macrophage Syk–PI3Kγ Inhibits Antitumor Immunity: SRX3207, a Novel Dual Syk–PI3K Inhibitory Chemotype Relieves Tumor Immunosuppression. Molecular Cancer Therapeutics. 2020.
