SRI-37240

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SRI-37240是一种有效的提前终止密码子 (PTCs) 抑制剂。SRI-37240 抑制 CFTR 的无义突变。在 HEK293T 细胞中，SRI-37240 改变 PTCs 的细胞翻译终止。当与 G418 使用联合时，SRI-37240 还能恢复原发性支气管上皮细胞的 CFTR 功能。

SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses CFTR nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418.

SRI-37240 (1, 3, 10 and 30 μM; 48 h) induces concentration-dependent increases in CFTR-dependent (Forskolin-stimulated and sensitive to the inhibitor CFTRInh-172) chloride conductance.SRI-37240 (10 μM; 72 h) significantly increases the amount of full-length, fully glycosylated form of CFTR protein, and the unprocessed, immature form of full-length CFTR protein in 16HBEge cells when co-treated with G418 (100 μM).SRI-37240 (10?μM; 24 h) alters cellular translation termination at PTCs in HEK293T cells, also increases global densities of ribosomes at normal stop codons without affecting densities of ribosomes in 3-UTRs.SRI-37240 (10?μM; 72 h) restores CFTR function in primary bronchial epithelial cells when combination with G418.Western Blot Analysis Cell Line:CFTR-G542X 16HBEg e Concentration:10?μM Incubation Time:24 h Result:Significantly increased the amount of Band C CFTR protein, which represents the full-length, fully glycosylated form of CFTR and Band B, which represents the unprocessed, immature form of full-length CFTR protein when combined with G418 (100 μM).

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Apoptosis

CFTR

CFTR

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883956-47-6

385.46

C24H23N3O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 11.36 mg/mL (29.47 mM; 超声助溶 (<60°C)

O=C1C=2C=CC=CC2N(C=3N=C(C=4C=CC=CC4)N(C(=O)C13)C5CCCCC5)C

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(-20℃)

With Ice Pack

≥ 2 years