SR8278
CAS No. 1254944-66-5
SR8278 ( —— )
产品货号. M21127 CAS No. 1254944-66-5
SR8278 is an REV-ERBα antagonist(EC50 = 0.47 μM) blocking activation of the receptor by the synthetic agonist GSK 4112.
纯度: >98% (HPLC)
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥1004 | 有现货 |
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10MG | ¥1596 | 有现货 |
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50MG | ¥3726 | 有现货 |
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100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称SR8278
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述SR8278 is an REV-ERBα antagonist(EC50 = 0.47 μM) blocking activation of the receptor by the synthetic agonist GSK 4112.
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产品描述SR8278 is an REV-ERBα antagonist(EC50 = 0.47 μM) blocking activation of the receptor by the synthetic agonist GSK 4112.
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同义词——
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通路Others
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靶点Other Targets
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受体REV-ERBα
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研究领域——
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适应症——
化学信息
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CAS Number1254944-66-5
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分子量361.48
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分子式C18H19NO3S2
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纯度>98% (HPLC)
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溶解度DMSO:10mg/ml(27.66mM)
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SMILESCCOC(=O)C1Cc2ccccc2CN1C(=O)c1ccc(SC)s1
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化学全称ethyl 2-{[5-(methylsulfanyl)thiophen-2-yl]carbonyl}-1234-tetrahydroisoquinoline-3-carboxylate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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Chicanine
Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
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P110
Dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity. Displays no effect on dynamin 1 or other mitochondrial dynamics-related proteins. Inhibits mitochondrial fission, dysfunction and reactive oxygen species (ROS) production in vitro. Reduces programmed cell death and improves cell viability by protecting mitochondrial integrity. Reduces mitochondrial fragmentation and mitochondrial ROS production in mouse model of Parkinson's disease. Cell permeable.
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Cholic Acid
ApplicationNon-denaturing ionic detergent used for extraction of membrane proteins.