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SR59230A
CAS No. 174689-39-5
SR59230A ( —— )
产品货号. M21725 CAS No. 174689-39-5
SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥567 | 有现货 |
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| 5MG | ￥883 | 有现货 |
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| 10MG | ￥1474 | 有现货 |
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| 25MG | ￥2924 | 有现货 |
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| 50MG | ￥4350 | 有现货 |
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| 100MG | ￥6278 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称SR59230A
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.
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产品描述MDMA (20 mg/kg) produces a slowly developing hyperthermia, reaching a maximum increase of 1.8°C at 130 min post injection. SR59230A (0.5 mg/kg) produces a small but significant attenuation of the slowly developing hyperthermia to MDMA. SR59230A (5 mg/kg) reveals a significant and marked early hypothermic reaction to MDMA.
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同义词——
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通路Angiogenesis
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靶点Adrenergic Receptor
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number174689-39-5
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分子量415.48
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分子式C23H29NO6
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纯度>98% (HPLC)
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溶解度DMSO : 31.25 mg/mL (75.21 mM; Need ultrasonic)
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SMILESO[C@@H](CN[C@H]1CCCC2=C1C=CC=C2)COC3=CC=CC=C3CC.O=C(O)C(O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Nisoli E, et al. Functional studies of the first selective beta 3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes.Mol Pharmacol. 1996 Jan;49(1):7-14.
2. Kanzler SA, et al. Involvement of β3-adrenergic receptors in the control of food intake in rats.Braz J Med Biol Res. 2011 Nov;44(11):1141-7.
3. Bruno G, et al. β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation.Oncogene. 2020 Jan;39(2):368-384.
产品手册
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