SR10067

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SR10067 是 Rev-Erbβ (IC50 = 160 nM) 和 Rev-Erbα (IC50 = 170 nM) 的有效、选择性和脑渗透激动剂，具有抗焦虑活性。

SR10067 is a potent, selective and brain penetrant agonist of Rev-Erbβ(IC50 = 160 nM) and Rev-Erbα(IC50 = 170 nM) with anxiolytic activity.

SR10067 has high affinity for Rev-Erbβ and Rev-Erbαwith IC50 values are 160 and 170 nM, respectively.

SR10067 (i.p.; 30 mg/kg) has good pharmacokinetic properties in mouse. Animal Model:Mice Dosage:30 mg/kg Administration:i.p.Result:Remained above the IC50 of the receptor in plasma and brain concentrations. Suppressed the circadian rhythm of Npas2 gene expression in the mouse hypothalamus in a single injection and had a dose-dependent effect on reduction in nocturnal wheel running activity. Induced wakefulness and reduced SWS and REM sleep and displayed high anxiolytic activity.

——

Others

Other Targets

——

——

——

1380548-02-6

465.593

C31H31NO3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (214.79 mM)

CC(C)(C)Oc1ccc(OCC2Cc3ccccc3CN2C(=O)c2cccc3ccccc23)cc1

——

(-20℃)

With Ice Pack

≥ 2 years