SQ609

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SQ609 是一种来自二哌啶库的先导化合物。SQ609 在 4μg/ml时抑制 90% 以上的细胞内细菌生长，并且对这些细胞有毒。SQ609 显示出强大的抗结核活性。

SQ609 is a lead compound from a library of dipiperidines. SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells. SQ609 displays a potent antitubercular activity .

In Mtb-infected macrophages in vitro, SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells.

SQ609 (10 mg/kg; intravenous injection) completely prevents weight loss in the Mtb-infected animals and prolongs the therapeutic effect following drug withdrawal for another 10-15 days.Animal Model:TB susceptible mice (C3H/He)Dosage:10 mg/kg Administration:I.v.Result:Prevented weight loss in the Mtb-infected animals and prolonged the therapeutic effect following drug withdrawal for another 10-15 days.

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GPCR/G Protein

Antibacterial

Antibacterial

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627052-25-9

346.55

C22H38N2O

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 6.67 mg/mL (19.25 mM; 超声助溶 (<60°C)

OC1CCN(CC2CCN(CC34CC5CC(CC(C5)C3)C4)CC2)CC1

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(-20℃)

With Ice Pack

≥ 2 years