SMER3

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SMER 3 是 Skp1-Cullin-F-box (SCF)(Met30) 泛素连接酶的抑制剂，该连接酶是 SCF E3 连接酶家族的成员，可调节多种细胞过程，包括转录、细胞周期控制和免疫反应。

SMER 3 is an inhibitor of the Skp1-Cullin-F-box (SCF)(Met30) ubiquitin ligase, a member of the SCF E3-ligase family, which regulates diverse cellular processes including transcription, cell-cycle control and immune response.(In Vitro):SMER 3 and rapidly increased PFKFB3 protein levels. Accordingly, ubiquitin-bound PFKFB3 was lower in E2- or G1-treated HUVECs. Both agents increased deubiquitinase USP19 levels through GPER signaling.(In Vivo):SMER 3 diminishes binding of the F-box subunit Met30 to the SCF core complex in vivo and show evidence for SMER 3 directly binding to Met30.

In yeast cells, Met4 ubiquitination is blocked in cells exposed to SMER3 (0-60 μM). The met4Δ cells are less susceptible to growth inhibition by SMER3.Addition of SMER3 to the ligase reactions inhibited ubiquitination of Met4 by SCFMet30 in a dose-dependent manner. SMER3 significantly inhibits the binding of Met30 to Skp1, and does not affect the Skp1 and Met30 protein levels.

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SMER 3 | SMER3

Others

Other Targets

mGluR5

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67200-34-4

224.18

C11H4N4O2

>98% (HPLC)

In Vitro:?DMSO : 12.5 mg/mL (55.76 mM)

O=C1C2=CC=CC=C2C3=NC4=NON=C4N=C31

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(-20℃)

With Ice Pack

≥ 2 years