SL-327

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SL327 是 MEK1/2 的选择性抑制剂，IC50 为 0.18 μM/0.22 μM；能够通过血脑屏障转运。

SL327 is a MEK inhibitor. SL327 blocks acquisition but not expression of lithium-induced conditioned place aversion: a behavioral and immunohistochemical study. SL327 had no affect on acquisition, expression, or extinction of EtOH-induced CPP in mice despite causing significant reduction of pERK levels in multiple brain regions. Additionally, although SL327 caused a generalized depression of locomotor activity, it did not prevent the development of EtOH-sensitization.

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SL327 | SL 327 | SL-327

Others

Other Targets

AP-1| MEK1| MEK2

Cancer

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305350-87-2

335.35

C16H12F3N3S

>98% (HPLC)

DMSO : 68 mg/mL 202.77 mM; Ethanol : 0.1 mg/mL 0.30 mM

c1ccc(c(c1)C(=C(N)Sc1ccc(cc1)N)C#N)C(F)(F)F

(E)-3-amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile

(-20℃)

With Ice Pack

≥ 2 years