SL-327 ( SL327; SL 327; SL-327 )

产品货号. M18397 CAS No. 305350-87-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SL-327
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.
产品描述

SL327 is a MEK inhibitor. SL327 blocks acquisition but not expression of lithium-induced conditioned place aversion: a behavioral and immunohistochemical study. SL327 had no affect on acquisition, expression, or extinction of EtOH-induced CPP in mice despite causing significant reduction of pERK levels in multiple brain regions. Additionally, although SL327 caused a generalized depression of locomotor activity, it did not prevent the development of EtOH-sensitization.
同义词

SL327; SL 327; SL-327
通路

Others
靶点

Other Targets
受体

AP-1; MEK1; MEK2
研究领域

Cancer
适应症

——

CAS Number

305350-87-2
分子量

335.35
分子式

C16H12F3N3S
纯度

98%
溶解度

DMSO : 68 mg/mL 202.77 mM; Ethanol : 0.1 mg/mL 0.30 mM;
SMILES

c1ccc(c(c1)C(=C(N)Sc1ccc(cc1)N)C#N)C(F)(F)F
化学全称

(E)-3-amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile

1. Scherle PA, wt al. J Biol Chem. 2000, 275(47), 37086-37092.

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