SIS3 ( SIS3 HCl )

产品货号. M14839 CAS No. 521984-48-5

选择性Smad3抑制剂；减弱 TGF-β1 依赖性 Smad3 磷酸化和 DNA 结合。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
2MG	￥421	有现货
5MG	￥915	有现货
10MG	￥1426	有现货
25MG	￥2940	有现货
50MG	￥4358	有现货
100MG	￥6221	有现货
500MG	￥12555	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

SIS3
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

选择性Smad3抑制剂；减弱 TGF-β1 依赖性 Smad3 磷酸化和 DNA 结合。
产品描述

Selective Smad3 inhibitor; attenuates TGF-β1-dependent Smad3 phosphorylation and Dna binding. Has no effect on Smad2, p38 MAPK, ERK or PI 3-kinase signaling. Inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts. Also inhibits TGF-β2-induced endothelial cell differentiation in iPSCs.(In Vitro):(E)-SIS3 (0.3-10 μM; for 1 hour) attenuates the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4.(E)-SIS3 (0.1?, 10, 50?μM; 30?min) significantly suppresses the expression of FN and α-SMA, but not that of Sphk2 provoked by TGF-β1.(E)-SIS3 (10 μM; 24 hours) significantly reduces both α-SMA and palladin expression that is enhanced by TWEAK in Primary human dermal fibroblasts.(E)-SIS3 significantly inhibits L4 development at five concentrations from as low as 2 μM to 50 μM (5 μM, 10 μM, 20 μM and 50 μM) in a dose-dependent manner.
体外实验

(E)-SIS3 (0.3-10 μM; for 1 hour) attenuates the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4. (E)-SIS3 (0.1?, 10, 50?μM; 30?min) significantly suppresses the expression of FN and α-SMA, but not that of Sphk2 provoked by TGF-β1. (E)-SIS3 (10 μM; 24 hours) significantly reduces both α-SMA and palladin expression that is enhanced by TWEAK in Primary human dermal fibroblasts. (E)-SIS3 significantly inhibits L4 development at five concentrations from as low as 2 μM to 50 μM (5 μM, 10 μM, 20 μM and 50 μM) in a dose-dependent manner. Western Blot Analysis Cell Line:Human dermal fibroblasts Concentration:0.3, 1, 3, 10 μM Incubation Time:For 1 hour Result:Attenuated the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4.
体内实验

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同义词

SIS3 HCl
通路

TGF-beta/Smad
靶点

TGFBR
受体

Smad3
研究领域

Cancer
适应症

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化学信息

CAS Number

521984-48-5
分子量

489.99
分子式

C28H27N3O3·HCl
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 30 mg/mL
SMILES

O=C(N1CC2=C(C=C(OC)C(OC)=C2)CC1)/C=C/C3=C(C4=CC=CC=C4)N(C)C5=NC=CC=C53.[H]Cl
化学全称

2-Propen-1-one, 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-, hydrochloride (1:1), (2E)-