SIG1459 ( SIG-1459;SIG 1459 )

产品货号. M13582 CAS No. 2234902-05-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SIG1459
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SIG1459 (SIG-1459) is a novel anti-acne isoprenylcysteine (IPC) small molecule that shows direct antibacterial activity and inhibits TLR2 inflammatory signaling.
产品描述

SIG1459 (SIG-1459) is a novel anti-acne isoprenylcysteine (IPC) small molecule that shows direct antibacterial activity and inhibits TLR2 inflammatory signaling; shows antibacterial activity against C. acnes (MIC= 8.5 uM, MBC =16.1 uM, and MBEC= 12.5 uM), inhibits TLR2 induced IL-8 release from TLR2/TLR2 (IC50= 0.086 uM), TLR2/6 (IC50= 0.209 uM) and IL-1α from TLR2/TLR2 (IC50 =0.050 uM); demonstrates in vivo anti-acne activity.
同义词

SIG-1459;SIG 1459
通路

GPCR/G Protein
靶点

Antibacterial
受体

Antibacterial
研究领域

——
适应症

——

CAS Number

2234902-05-5
分子量

584.77
分子式

C29H50N2Na2O5S
纯度

>98% (HPLC)
溶解度

——
SMILES

CC(C)CCCC(C)CCCC(C)CCCC(=CCSCC(C(=O)[O-])NC(=O)N1CCCC1C(=O)[O-])C.[Na+].[Na+]
化学全称

(((1R)-1-carboxy-2-(((E)-3,7,11,15-tetramethylhexadec-2-en-1-yl)thio)ethyl)carbamoyl)proline disodium salt

1. Fernández JR, et al. Exp Dermatol. 2018 Sep;27(9):993-999.

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