SIG1459
CAS No. 2234902-05-5
SIG1459 ( SIG-1459;SIG 1459 )
产品货号. M13582 CAS No. 2234902-05-5
SIG1459 (SIG-1459) is a novel anti-acne isoprenylcysteine (IPC) small molecule that shows direct antibacterial activity and inhibits TLR2 inflammatory signaling.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称SIG1459
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述SIG1459 (SIG-1459) is a novel anti-acne isoprenylcysteine (IPC) small molecule that shows direct antibacterial activity and inhibits TLR2 inflammatory signaling.
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产品描述SIG1459 (SIG-1459) is a novel anti-acne isoprenylcysteine (IPC) small molecule that shows direct antibacterial activity and inhibits TLR2 inflammatory signaling; shows antibacterial activity against C. acnes (MIC= 8.5 uM, MBC =16.1 uM, and MBEC= 12.5 uM), inhibits TLR2 induced IL-8 release from TLR2/TLR2 (IC50= 0.086 uM), TLR2/6 (IC50= 0.209 uM) and IL-1α from TLR2/TLR2 (IC50 =0.050 uM); demonstrates in vivo anti-acne activity.
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同义词SIG-1459;SIG 1459
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通路GPCR/G Protein
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靶点Antibacterial
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受体Antibacterial
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研究领域——
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适应症——
化学信息
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CAS Number2234902-05-5
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分子量584.77
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分子式C29H50N2Na2O5S
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纯度>98% (HPLC)
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溶解度——
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SMILESCC(C)CCCC(C)CCCC(C)CCCC(=CCSCC(C(=O)[O-])NC(=O)N1CCCC1C(=O)[O-])C.[Na+].[Na+]
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化学全称(((1R)-1-carboxy-2-(((E)-3,7,11,15-tetramethylhexadec-2-en-1-yl)thio)ethyl)carbamoyl)proline disodium salt
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Fernández JR, et al. Exp Dermatol. 2018 Sep;27(9):993-999.
产品手册
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