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SHIN1
CAS No. 2146095-85-2
SHIN1 ( RZ-2994 )
产品货号. M26439 CAS No. 2146095-85-2
SHIN1 is an inhibitor of human serine hydroxymethyltransferse 1(SHMT1) with IC50 of 5 nM and human serine hydroxymethyltransferse 2 (SHMT2) with an IC50 of 13 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2527 | 有现货 |
|
| 10MG | ￥4277 | 有现货 |
|
| 25MG | ￥6958 | 有现货 |
|
| 50MG | ￥9639 | 有现货 |
|
| 100MG | ￥12798 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称SHIN1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述SHIN1 is an inhibitor of human serine hydroxymethyltransferse 1(SHMT1) with IC50 of 5 nM and human serine hydroxymethyltransferse 2 (SHMT2) with an IC50 of 13 nM.
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产品描述SHIN1 is an inhibitor of human serine hydroxymethyltransferse 1(SHMT1) with IC50 of 5 nM and human serine hydroxymethyltransferse 2 (SHMT2) with an IC50 of 13 nM.(In Vitro):SHIN1 inhibits the growth of SHMT2 deletion HCT-116 cells (IC50 = 10 nM). SHIN1 inhibits SHMT1/2 in HCT-116 cells. SHIN1 blocks cell growth through a progressive depletion of purines, leading to loss of nucleotide triphosphates. SHIN1 is particularly active against B-cell malignancies.
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同义词RZ-2994
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通路Others
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靶点Other Targets
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受体HMG-CoA reductase
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研究领域——
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适应症——
化学信息
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CAS Number2146095-85-2
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分子量400.5
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分子式C24H24N4O2
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纯度>98% (HPLC)
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溶解度——
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SMILESCC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)-c1ccccc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Morikawa S, et al. Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells. J Atheroscler Thromb. 2000;7(3):138-44.
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