SGC-CBP30 ( SGC-CBP30 | SGC-CBP 30 | SGC-CBP-30 )

产品货号. M17342 CAS No. 1613695-14-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SGC-CBP30
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SGC-CBP30 是一种有效的 CREBBP/EP300 抑制剂 (IC50: 21/38 nM)。
产品描述

SGC-CBP30 is a potent and selective inhibitor of CREBBP (CBP) and EP300; which are general transcriptional co-activators. CREBBP has also been associated with Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig?’s disease, a neurodegenerative disease with progressive degeneration of motor neurons in the brain and spinal cord, Alzheimer's disease and poly glutamine repeat diseases such as Spinal and Bulbar Muscular Atrophy and Huntington?’s disease.
体外实验

——
体内实验

Animal Model:Sprague-Dawley (SD) rats (aged 3-4 weeks) injected with NSC-125066 Dosage:25 mg/kg Administration:Oral administration; daily; for 14 days Result:Slightly alleviated alveolar bronchial fibrosis induced by NSC-125066.
同义词

SGC-CBP30 | SGC-CBP 30 | SGC-CBP-30
通路

Others
靶点

Other Targets
受体

CREBBP| EP300
研究领域

Cancer
适应症

——

CAS Number

1613695-14-9
分子量

509.04
分子式

C28H33CIN4O3
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 31 mg/mL; 60.90 mM
SMILES

Cc1noc(C)c1c1cc2nc(CCc3ccc(OC)c(Cl)c3)n(C[C@H](C)N3CCOCC3)c2cc1
化学全称

(S)-4-(1-(2-(3-chloro-4-methoxyphenethyl)-5-(3,5-dimethylisoxazol-4-yl)-1H-benzo[d]imidazol-1-yl)propan-2-yl)morpholine

1. Structural Genomics Consortium

计算器

产品手册

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