SEMBL

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SEMBL 是一种有效的 NF-κB 抑制剂，可抑制 NF-κB 成分 p65 的 DNA 结合。

SEMBL is a potent NF-κB inhibitor that inhibits DNA binding of NF-κB component p65; inhibits LPS-induced NF-κB activation, iNOS expression, and inflammatory cytokine secretions; also inhibits NF-κB and cellular invasion in ovarian carcinoma ES-2 cells; enhances stability in aqueous solution compared with (-)-DHMEQ.

SEMBL inhibits MMP-2 expression and cellular metastatic activity in ovarian carcinoma cells.SEMBL inhibits the cell-free DNA binding of NF-κB in the ES-2 nuclear extract and inhibits the constitutively activated NF-κB activity in ovarian carcinoma cells.SEMBL inhibits cellular migration, invasion and MMP-2 expression in ovarian carcinoma cells at non-toxic concentrations.

——

SEMBL

Apoptosis

NF-κB

NF-κB

——

——

1443448-82-5

233.223

C12H11NO4

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (428.78 mM)

C=C([C@H](NC(C1=CC=CC=C1O)=O)CO2)C2=O

(S)-2-hydroxy-N-(4-methylene-5-oxotetrahydrofuran-3-yl)benzamide

(-20℃)

With Ice Pack

≥ 2 years