
SCR130
CAS No. 2377858-38-1
SCR130 ( 1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo- )
产品货号. M24094 CAS No. 2377858-38-1
1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-氯苯基)-8-thioxo- 具有酶抑制、抗增殖作用和抗真菌活性。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥446 | 有现货 |
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10MG | ¥583 | 有现货 |
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25MG | ¥1393 | 有现货 |
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50MG | ¥2130 | 有现货 |
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100MG | ¥3183 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称SCR130
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-氯苯基)-8-thioxo- 具有酶抑制、抗增殖作用和抗真菌活性。
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产品描述1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo- is enzyme inhibition, antiproliferative effects and antifungal activity.
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体外实验SCR130 (7-21 μM; 48 hours) increase in the number of late and early apoptotic cells. SCR130 induces apoptosis by both intrinsic and extrinsic pathways. SCR130 increases the expression of p-p53, BCL2 and MCL1, and CYTOCHROME C, BAX, and BAK also increaseed. The activation of caspase 8, increase in expression of FAS and SMAC-DIABLO proteins are also observed.SCR130 (48 hours) exhibits cytotoxicity in Reh, HeLa, CEM, Nalm6, and N114 cells with IC50 values of 14.1 μM, 5.9 μM, 6.5 μM, 2.2 μM, and 11 μM, respectively.SCR130 can potentiate the effect of radiation (0.5 and 1 Gy) by inducing enhanced cell death upon coadministration in Reh and Nalm6 cell lines.SCR130 blocks the endogenous NHEJ leading to accumulation of unrepaired DNA breaks. Treatment with SCR130 leads to inhibition of endogenous NHEJ, resulting in the accumulation of DNA double-strand breaks (DSBs) and cell death by activating apoptotic pathways.:Apoptosis Analysis Cell Line:Reh cells Concentration:7 μM, 14 μM, and 21 μM Incubation Time:48 hours Result:Showed a concentration-dependent increase in the number of late and early apoptotic cells.Western Blot Analysis Cell Line:Reh cells Concentration:7 μM, 14 μM, and 21 μM Incubation Time:48 hoursResult:Revealed a concentration-dependent increase in levels of pATM and activation of p53 through phosphorylation.
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体内实验——
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同义词1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number2377858-38-1
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分子量418.3
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分子式C19 H13 Cl2 N3 O2 S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (239.06 mM)
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SMILESO=C(NC(NC1=O)=S)C21C(C3=CC=C(Cl)C=C3)CC(C4=CC=C(Cl)C=C4)=N2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Gopinatha V K , Swarup H A , Raghavan S C , et al. Discovery of Novel Approach for Regioselective Synthesis of Thioxotriaza-Spiro Derivatives via Oxalic Acid[J]. Synlett, 2019, 30(17):2004.
产品手册




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