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SCH-00013
CAS No. 217963-18-3
SCH-00013 ( SCH 00013;SCH00013 )
产品货号. M13480 CAS No. 217963-18-3
A novel cardiotonic agent that acts as a calcium sensitizer with no chronotropic activity in mammalian cardiac muscle.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2827 | 有现货 |
|
| 50MG | ￥10692 | 有现货 |
|
| 100MG | ￥16119 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称SCH-00013
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A novel cardiotonic agent that acts as a calcium sensitizer with no chronotropic activity in mammalian cardiac muscle.
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产品描述A novel cardiotonic agent that acts as a calcium sensitizer with no chronotropic activity in mammalian cardiac muscle, elicits positive inotropic effect in dog and rabbit ventricular muscles (EC50=9.2 uM); also weakly inhibits PDE3 with IC50 of 64.9 uM; improved left ventricular dysfunction and survival prognosis of dilated cardiomyopathy in a mouse model; orally bioavailable.Heart Failure Preclinical
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同义词SCH 00013;SCH00013
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通路Angiogenesis
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靶点PDE
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受体PDE
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研究领域Cardiovascular Disease
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适应症——
化学信息
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CAS Number217963-18-3
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分子量324.38
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分子式C18H20N4O2
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纯度>98% (HPLC)
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溶解度DMSO
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SMILESC1CC(=O)NN=C1C2=CCN(CC2)CC(C3=CC=C(C=C3)C#N)O
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化学全称Benzonitrile, 4-[2-[3,6-dihydro-4-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-1(2H)-pyridinyl]-1-hydroxyethyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Sugawara H, et al. J Pharmacol Exp Ther. 1998 Oct;287(1):214-22.
2. Hino M, et al. Arzneimittelforschung. 1999 May;49(5):398-406.
3. Yoshimura A, et al. Arzneimittelforschung. 1999 May;49(5):407-11.
4. Arimura T, et al. J Am Coll Cardiol. 2010 Apr 6;55(14):1503-5.
2. Hino M, et al. Arzneimittelforschung. 1999 May;49(5):398-406.
3. Yoshimura A, et al. Arzneimittelforschung. 1999 May;49(5):407-11.
4. Arimura T, et al. J Am Coll Cardiol. 2010 Apr 6;55(14):1503-5.
产品手册
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