SC-26196

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SC-26196 是一种口服活性的 Delta6 去饱和酶 (D6D) 抑制剂，在大鼠肝微粒体测定中 IC50 为 0.2 μM，具有抗炎特性。

SC-26196 is an orally active inhibitor of Delta6 desaturase (D6D) with IC50 of 0.2 μM in a rat liver microsomal assay, with antiinflammatory properties. The FADS2 inhibitor SC26196 reduced PBMC, but not Jurkat cell, proliferation suggesting PUFA synthesis is involved in regulating mitosis in PBMCs.

SC-26196 (200nM) inhibits proliferation of peripheral blood mononuclear cells (PBMCs), but Not Jurkat Cells. Cell Proliferation Assay Cell Line:PBMCs and Jurkat cells Concentration:200?nM Incubation Time:96 hours for PBMCs; 144 hours for Jurkat cells Result:Treatment of PBMCs significantly decreased the proportion of cells that underwent division, the division index and proliferation index.

SC-26196 ( included in the diet at 0, 0.07, 0.21, or 0.7 mg/kg diet to achieve dosages of 0, 10, 30, and 100 mg/kg per day) causes a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver. Feeding 100 mg SC-26196 per kg BW per day inhibits the Δ6-desaturase enzyme. Animal Model:Male mice (12- or 15-week-old)Dosage:0, 10, 30, and 100 mg/kg per day Administration:Included in the diet at 0, 0.07, 0.21, or 0.7mg/kg diet to achieve dosages of 0, 10, 30, and 100mg/kg per day.Result:Caused a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver.

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Others

Other Targets

D6D

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218136-59-5

423.55

C27H29N5

>98% (HPLC)

DMSO:4mg/ml (9.44 Mm; Need ultrasonic)

C1CN(CCN1CCCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)N=CC4=CN=CC=C4

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(-20℃)

With Ice Pack

≥ 2 years