SBI-477

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SBI-477 是一种化学探针，通过灭活转录因子 MondoA 来刺激胰岛素信号传导。 SBI-477 协同抑制三酰甘油 (TAG) 合成并增强人骨骼肌细胞的基础葡萄糖摄取。

SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA. SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes. SBI-477, that coordinately inhibited triacylglyceride (TAG) synthesis and enhanced basal glucose uptake in human skeletal myocytes.??SBI-477 stimulated insulin signaling by deactivating the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4).?Depleting MondoA in myocytes reproduced the effects of SBI-477 on glucose uptake and myocyte lipid accumulation.?

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Others

Other Targets

Others

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781628-99-7

483.54

C24H25N3O6S

>98% (HPLC)

DMSO:65 mg/mL (134.43 mM; Need ultrasonic)

O=C(NC1=NC(C2=CC=C(OC)C=C2)=CS1)C3=CC=C(OCC(N4CCOCC4)=O)C(OC)=C3

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(-20℃)

With Ice Pack

≥ 2 years