SAH-EZH2 ( —— )

产品货号. M30795 CAS No. 1453222-26-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SAH-EZH2
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

EZH2/EPP interaction inhibitor (Kd = 320 nM). Suppresses EZH2 expression and H3K27 trimethylation by PCR2 complex. Arrests proliferation and induces monocyte to macrophage differentiation of MLL-AF9 leukemia cell line.
产品描述

EZH2/EPP interaction inhibitor (Kd = 320 nM). Suppresses EZH2 expression and H3K27 trimethylation by PCR2 complex. Arrests proliferation and induces monocyte to macrophage differentiation of MLL-AF9 leukemia cell line.
体外实验

The selectivity of SAH-EZH2 activity is highlighted by the lack of a SAH-EZH2 effect on the H3K4, H3K9 and H3K36 methyl marks. MLL-AF9 leukemia cells, which are dependent on PRC2, undergo growth arrest and monocyte-macrophage differentiation upon treatment with SAH-EZH2, consistent with observed changes in expression of PRC2-regulated, lineage-specific marker genes.
体内实验

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同义词

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通路

Chromatin/Epigenetic
靶点

Histone Demethylase
受体

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研究领域

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适应症

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CAS Number

1453222-26-8
分子量

3432.05
分子式

C155H256N48O40
纯度

>98% (HPLC)
溶解度

water:1 mg/mL
SMILES

[H][C@]([C@H](O)C)(C(N[C@H](C(N[C@@]([C@H](CC)C)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@]([C@H](CC)C)(C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)C(C)C)=O)=O)CCC(N)=O)=O)[H])=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCCN)=O)CC2=CNC3=CC=CC=C23)=O)CCC(O)=O)=O)CCC(N)=O)=O)CC(N)=O)=O)CC(C)C)=O)[H])=O)CCC(N)=O)=O)NC([C@@H](NC([C@@]4(CCC/C=C/CCC[C@](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC5=CC=CC=C5)=O)CO)=O)CO)=O)CC(N)=O)=O)CCCNC(N)=N)=O)(C(N[C@H](C(N[C@@]([C@H](CC)C)(C(N[C@H](C(N4)=O)CC(C)C)=O)[H])=O)CCCCN)=O)C)C)=O)CCCNC(N)=N)=O
化学全称

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