
S1p-receptor-agonist-1
CAS No. 1514888-56-2
S1p-receptor-agonist-1 ( S1P-agonist-1 | DC10392 | S1p receptor agonist 1 )
产品货号. M17329 CAS No. 1514888-56-2
S1P 受体激动剂。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥1320 | 有现货 |
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10MG | ¥2333 | 有现货 |
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25MG | ¥3929 | 有现货 |
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50MG | ¥5613 | 有现货 |
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100MG | ¥7995 | 有现货 |
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500MG | ¥15957 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称S1p-receptor-agonist-1
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述S1P 受体激动剂。
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产品描述S1p receptor agonist 1 is an S1P receptor agonist extracted from patent WO 2015039587 A1, compound example 2. Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. S1P inhibits the collagen-induced human platelet activation through S1PR4 but not S1PR1.
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体外实验——
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体内实验Icanbelimod (oral administration; 0.01 mg/kg-1 mg/kg) at all dose is active, and only a dose of 0.01 mg/kg is required to observe a decrease in the number of peripheral blood lymphocytes by more than 50% and a decrease in the 1 mg/kg dose. Besides, this compound islymphocyte-specific, which dose not significantly alter the number of peripheral monocytes and other white blood cells in SD rats.Icanbelimod (oral administration; 3 mg/kg; 12 days)is has been proved to block lymphocyte efflux. In the development of type II collagen-induced arthritis in rat model, compound 2 is effective in inhibiting the development of joint swelling in arthritis andjoint structure destruction.Icanbelimod (oral administration; 0.3-1mg/kg; 30 days; once daily) inhibits the development of experimental autoimmune encephalitis (EAE) as a dose-dependent manner in mice model. Animal Model:Lewis ratsDosage:3 mg/kgAdministration:Oral administrationResult:Decreased the severity score of arthritis in the four-legged rats.Animal Model:Female C57BL/6 mice?Dosage:0.03, 0.1, and 1 mg/kg Administration:Oral administration Result:Decreased the severity score of EAE in MOG 35-55?induced mice.
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同义词S1P-agonist-1 | DC10392 | S1p receptor agonist 1
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通路Others
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靶点Other Targets
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受体S1P
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研究领域——
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适应症——
化学信息
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CAS Number1514888-56-2
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分子量409.45
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分子式C23H24FN3O3
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纯度>98% (HPLC)
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溶解度DMSO : 6.8 mg/mL. 16.61 mM;
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SMILESc1c(ccc(c1)CC(C)C)c1nc(no1)c1ccc(c(c1)F)CN1CC(C1)C(=O)O
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化学全称1-{2-Fluoro-4-[5-(4-isobutyl-phenyl)-[1,2,4]oxadiazol-3-yl]-benzyl}-azetidine-3-carboxylic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.WO 2015039587 A1
产品手册




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