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Rolipram
CAS No. 61413-54-5
Rolipram ( SB95952;ZK62711;(R,S)-Rolipram;SB 95952;ZK 62711;SB-95952;ZK-62711 )
产品货号. M15314 CAS No. 61413-54-5
A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥348 | 有现货 |
|
| 50MG | ￥494 | 有现货 |
|
| 100MG | ￥705 | 有现货 |
|
| 200MG | ￥1037 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Rolipram
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
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产品描述A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively; increases phosphorylation of CREB in U937 cells in a dose-dependent fashion, dose-dependently inhibits the IFN-gamma-stimulated phosphorylation of p38 MAPK with IC50 of 290 nM; inhibits TNF production, attenuates carrageenan-induced paw inflammation in mice.Asthma Phase 2 Clinical
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同义词SB95952;ZK62711;(R,S)-Rolipram;SB 95952;ZK 62711;SB-95952;ZK-62711
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通路Angiogenesis
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靶点PDE
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受体PDE4B;PDE4D
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研究领域Inflammation/Immunology
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适应症Asthma
化学信息
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CAS Number61413-54-5
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分子量275.34
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分子式C16H21NO3
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 41 mg/mL
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SMILESO=C1NCC(C2=CC=C(OC)C(OC3CCCC3)=C2)C1
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化学全称2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. MacKenzie SJ, et al. Biochem J. 2000 Apr 15;347(Pt 2):571-8.
2. Korhonen R, et al. Br J Pharmacol. 2013 Aug;169(7):1525-36.
3. Shalaby AM, et al. J Pharmacol Pharmacother. 2012 Apr;3(2):132-7.
2. Korhonen R, et al. Br J Pharmacol. 2013 Aug;169(7):1525-36.
3. Shalaby AM, et al. J Pharmacol Pharmacother. 2012 Apr;3(2):132-7.
产品手册
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