Rolapitant
CAS No. 552292-08-7
Rolapitant ( SCH619734 )
产品货号. M17539 CAS No. 552292-08-7
Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity.
纯度: 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥486 | 有现货 |
|
5MG | ¥689 | 有现货 |
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10MG | ¥1021 | 有现货 |
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25MG | ¥1604 | 有现货 |
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50MG | ¥2657 | 有现货 |
|
100MG | ¥3969 | 有现货 |
|
500MG | ¥8829 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Rolapitant
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity.
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产品描述Rolapitant Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy. Compared to other NK1-receptor antagonists, rolapitant has both a more rapid onset of action and a much longer half-life.
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同义词SCH619734
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通路Others
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靶点Other Targets
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受体NK1
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研究领域Cancer
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适应症——
化学信息
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CAS Number552292-08-7
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分子量500.48
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分子式C25H26F6N2O2
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纯度98%
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溶解度DMSO : ≥ 30 mg/mL; 59.94 mM
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SMILESC[C@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)OC[C@]1(CC[C@]2(CCC(=O)N2)CN1)c1ccccc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Rapoport B, et al. Eur J Y. 2016 Apr;57:23-30.
产品手册
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