Riociguat ( BAY 63-2521; BAY63-2521; Riociguat )

产品货号. M18919 CAS No. 625115-55-1

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

Riociguat
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Riociguat is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension.
产品描述

Riociguat, also known as BAY 63-2521, is a novel drug that is currently in clinical development by Bayer. It is a stimulator of soluble guanylate cyclase (sGC). At the moment Phase III clinical trials investigate the use of riociguat as a new approach to treat two forms of pulmonary hypertension (PH): chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). Riociguat constitutes the first drug of a novel class of sGC stimulators.
同义词

BAY 63-2521; BAY63-2521; Riociguat
通路

Others
靶点

Other Targets
受体

Guanylate cyclase
研究领域

Cardiovascular Disease
适应症

——

CAS Number

625115-55-1
分子量

422.42
分子式

C20H19FN8O2
纯度

98%
溶解度

DMSO : ≥ 50 mg/mL; 118.37 mM
SMILES

C(=O)(N(C)c1c(nc(nc1N)c1c2c(nccc2)n(n1)Cc1c(cccc1)F)N)OC
化学全称

methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate

1. Schermuly RT, et al. Eur Respir J. 2008, 32(4), 881-891.

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